Vitamin D status and severity of COVID-19.

Autor: Nielsen NM; Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark. NMN@ssi.dk.; Focused Research Unit in Neurology, Department of Neurology, Hospital of Southern Jutland, University of Southern Denmark, Aabenraa, Denmark. NMN@ssi.dk., Junker TG; Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark., Boelt SG; Section for Clinical Mass Spectrometry, Danish Center for Neonatal Screening, Department of Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark.; iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Copenhagen, Denmark., Cohen AS; Test Center Denmark, Statens Serum Institut, Copenhagen, Denmark., Munger KL; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA., Stenager E; Focused Research Unit in Neurology, Department of Neurology, Hospital of Southern Jutland, University of Southern Denmark, Aabenraa, Denmark.; Multiple Sclerosis Clinic of Southern Jutland (Sønderborg, Kolding, Esbjerg), Department of Neurology, Hospital of Southern Jutland, University of Southern Denmark, Sønderborg, Denmark., Ascherio A; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.; Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Boding L; The Danish National Biobank, Statens Serum Institut, Copenhagen, Denmark., Hviid A; Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.; Pharmacovigilance Research Centre, Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2022 Nov 17; Vol. 12 (1), pp. 19823. Date of Electronic Publication: 2022 Nov 17.
DOI: 10.1038/s41598-022-21513-9
Abstrakt: We explored the association between COVID-19 severity and vitamin D status using information from Danish nation-wide health registers, the COVID-19 surveillance database and stored blood samples from the national biobank. 25-hydroxyvitamin D (25(OH)D) was measured using tandem mass spectroscopy. The association between 25(OH)D levels and COVID-19 severity, classified hierarchical as non-hospitalized, hospitalized but not admitted to an intensive care unit (ICU), admitted to ICU, and death, was evaluated by proportional odds ratios (POR) assuming proportionality between the four degrees of severity. Among 447 adults tested SARS-CoV-2 positive in the spring of 2020, low levels of 25(OH)D were associated with a higher risk of severe COVID-19. Thus, odds of experiencing more severe COVID-19 among individuals with insufficient (25 to < 50 nmol/L) and sufficient (≥ 50 nmol/L) 25(OH)D levels were approximately 50% of that among individuals with deficient levels (< 25 nmol/L) (POR = 0.49 (95% CI 0.25-0.94), POR = 0.51 (95% CI 0.27-0.96), respectively). Dividing sufficient vitamin D levels into 50 to < 75 nmol/L and ≥ 75 nmol/L revealed no additional beneficial effect of higher 25(OH)D levels. In this observational study, low levels of 25(OH)D were associated with a higher risk of severe COVID-19. A possible therapeutic role of vitamin D should be evaluated in well-designed interventional studies.
(© 2022. The Author(s).)
Databáze: MEDLINE
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