Agreement between multiparametric MRI (PIVOT), Doppler ultrasound, and near-infrared spectroscopy-based assessments of skeletal muscle oxygenation and perfusion.

Autor: Luck JC; Penn State Heart and Vascular Institute, Pennsylvania State University College of Medicine, Milton S. Hershey Medical Center, Hershey, PA, United States of America., Sica CT; Department of Radiology, Pennsylvania State University College of Medicine, Milton S. Hershey Medical Center, Hershey, PA, United States of America., Blaha C; Penn State Heart and Vascular Institute, Pennsylvania State University College of Medicine, Milton S. Hershey Medical Center, Hershey, PA, United States of America., Cauffman A; Penn State Heart and Vascular Institute, Pennsylvania State University College of Medicine, Milton S. Hershey Medical Center, Hershey, PA, United States of America., Vesek J; Department of Molecular Biology, Pennsylvania State University College of Medicine, Milton S. Hershey Medical Center, Hershey, PA, United States of America., Eckenrode J; School of Medicine, University of South Carolina, Columbia, SC, United States of America., Stavres J; Penn State Heart and Vascular Institute, Pennsylvania State University College of Medicine, Milton S. Hershey Medical Center, Hershey, PA, United States of America; School of Kinesiology and Nutrition, University of Southern Mississippi, Hattiesburg, MS, United States of America. Electronic address: Jonathon.Stavres@usm.edu.
Jazyk: angličtina
Zdroj: Magnetic resonance imaging [Magn Reson Imaging] 2023 Feb; Vol. 96, pp. 27-37. Date of Electronic Publication: 2022 Nov 14.
DOI: 10.1016/j.mri.2022.11.003
Abstrakt: Skeletal muscle perfusion and oxygenation are commonly evaluated using Doppler ultrasound and near-infrared spectroscopy (NIRS) techniques. However, a recently developed magnetic resonance imaging (MRI) sequence, termed PIVOT, permits the simultaneous collection of skeletal muscle perfusion and T2* (an index of skeletal muscle oxygenation).
Purpose: To determine the level of agreement between PIVOT, Doppler ultrasound, and NIRS-based assessments of skeletal muscle perfusion and oxygenation.
Methods: Twelve healthy volunteers (8 females, 25 ± 3 years, 170 ± 11 cm, 71.5 ± 8.0 kg) performed six total reactive hyperemia protocols. During three of these reactive hyperemia protocols, Tissue Saturation Index (TSI) and oxygenated hemoglobin (O 2 Hb) were recorded from the medial gastrocnemius (MG) and tibialis anterior (TA), and blood flow velocity was recorded from the popliteal artery (BFv pop ) via Doppler Ultrasound. The other three trials were performed inside the bore of a 3 T MRI scanner, and the PIVOT sequence was used to assess perfusion (PIVOT perf ) and oxygenation (T2*) of the medial gastrocnemius and tibialis anterior muscles. Positive incremental areas under the curve (iAUC) and times to peak (TTP) were calculated for each variable, and the level of agreement between collection methods was evaluated via Bland-Altman analyses and Spearman's Rho correlation analyses.
Results: The only significant bivariate relationships observed were between the T2* vs. TSI iAUC and PIVOT perf vs. BFv pop values recorded from the MG. Significant mean differences were observed for all comparisons (all P ≤ 0.038), and significant proportional biases were observed for the PIVOT perf vs. tHb TTP (R 2  = 0.848, P < 0.001) and T2* vs. TSI TTP comparisons in the TA (R 2  = 0.488, P = 0.011), and the PIVOT perf vs. BFv pop iAUC (R 2  = 0.477, P = 0.013) and time to peak (R 2  = 0.851, P < 0.001) comparisons in the MG.
Conclusions: Our findings suggest that the PIVOT technique has, at best, a moderate level of agreement with Doppler ultrasound and NIRS assessment methods and is subject to significant proportional bias. These findings do not challenge the accuracy of either measurement technique but instead reflect differences in the vascular compartments, sampling volumes, and parameters being evaluated.
Competing Interests: Declaration of Competing Interest The authors have no conflicts of interest to report.
(Copyright © 2022 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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