Naphazoline and oxymetazoline are superior to epinephrine in enhancing the cutaneous analgesia of lidocaine in rats.

Autor: Chou AK; Department of Anesthesiology, China Medical University Hospital, Taichung, Taiwan.; School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan., Chiu CC; Department of General Surgery, E-Da Cancer Hospital, Kaohsiung, Taiwan.; School of Medicine, College of Medicine, I-Shou University, Kaohsiung, Taiwan., Zhu GC; Department of Physical Therapy, College of Medicine, National Cheng Kung University, Tainan, Taiwan., Wang JJ; Department of Anesthesiology, Tri-Service General Hospital & National Defense Medical Center, Taipei, Taiwan.; Department of Medical Research, Chi-Mei Medical Center, Tainan, Taiwan., Chen YW; Department of Medical Research, Chi-Mei Medical Center, Tainan, Taiwan.; Department of Physical Therapy, College of Health Care, China Medical University, Taichung, Taiwan., Hung CH; Department of Physical Therapy, College of Medicine, National Cheng Kung University, Tainan, Taiwan.; Institute of Allied Health Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Jazyk: angličtina
Zdroj: Fundamental & clinical pharmacology [Fundam Clin Pharmacol] 2023 Apr; Vol. 37 (2), pp. 296-304. Date of Electronic Publication: 2022 Nov 28.
DOI: 10.1111/fcp.12853
Abstrakt: This study observed the cutaneous analgesic effect of adrenergic agonists when combined with lidocaine. We aimed at the usefulness of four adrenergic agonists and epinephrine as analgesics or as tools to prolong the effect of local anesthetics using a model of cutaneous trunci muscle reflex (pinprick pain) in rats. We showed that subcutaneous four adrenergic agonists and epinephrine, as well as the local anesthetic bupivacaine and lidocaine, developed a concentration-dependent cutaneous analgesia. The rank order of the efficacy of different compounds (ED 50 ; median effective dose) was epinephrine [0.013 (0.012-0.014) μmol] > oxymetazoline [0.25 (0.22-0.28) μmol] > naphazoline [0.42 (0.34-0.53) μmol] = bupivacaine [0.43 (0.37-0.50) μmol] > xylometazoline [1.34 (1.25-1.45) μmol] > lidocaine [5.86 (5.11-6.72) μmol] > tetrahydrozoline [6.76 (6.21-7.36) μmol]. The duration of full recovery caused by tetrahydrozoline, oxymetazoline, or xylometazoline was greater (P < 0.01) than that induced via epinephrine, bupivacaine, lidocaine, or naphazoline at equianesthetic doses (ED 25 , ED 50 , and ED 75 ). Co-administration of lidocaine (ED 50 ) with four adrenergic agonists or epinephrine enhanced the cutaneous analgesic effect. We observed that four adrenergic agonists and epinephrine induce analgesia by themselves, and such an effect has a longer duration than local anesthetics. Co-administration of lidocaine with the adrenergic agonist enhances the analgesic effect, and the cutaneous analgesic effect of lidocaine plus naphazoline (or oxymetazoline) is greater than that of lidocaine plus epinephrine.
(© 2022 Société Française de Pharmacologie et de Thérapeutique. Published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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