Obesity as a comorbidity in children and adolescents with autoimmune rheumatic diseases.

Autor: Held M; Division of Clinical Immunology, Rheumatology and Allergology, Department of Pediatrics, Centre of Reference for Paediatric and Adolescent Rheumatology of Ministry of Health of the Republic Croatia, University Hospital Centre Zagreb, University of Zagreb School of Medicine, Kispaticeva 12, 10 000, Zagreb, Croatia., Sestan M; Division of Clinical Immunology, Rheumatology and Allergology, Department of Pediatrics, Centre of Reference for Paediatric and Adolescent Rheumatology of Ministry of Health of the Republic Croatia, University Hospital Centre Zagreb, University of Zagreb School of Medicine, Kispaticeva 12, 10 000, Zagreb, Croatia., Jelusic M; Division of Clinical Immunology, Rheumatology and Allergology, Department of Pediatrics, Centre of Reference for Paediatric and Adolescent Rheumatology of Ministry of Health of the Republic Croatia, University Hospital Centre Zagreb, University of Zagreb School of Medicine, Kispaticeva 12, 10 000, Zagreb, Croatia. marija.jelusic@mef.hr.
Jazyk: angličtina
Zdroj: Rheumatology international [Rheumatol Int] 2023 Feb; Vol. 43 (2), pp. 209-219. Date of Electronic Publication: 2022 Nov 17.
DOI: 10.1007/s00296-022-05238-6
Abstrakt: Childhood obesity is the public health issue with alarming rates recorded throughout developed world and an important modifiable health risk for developing various chronic diseases, with childhood-onset autoimmune rheumatic diseases among them also. The aim of this article was to summarize epidemiological, pathophysiological and clinical implication of obesity on juvenile idiopathic arthritis (JIA), childhood-onset systemic lupus erythematosus (cSLE), juvenile dermatomyositis (JDM), IgA vasculitis (IgAV) and Kawasaki disease (KD). We reviewed PubMed database and selected 74 relevant articles. Epidemiological data of obesity among children with autoimmune rheumatic diseases indicate an increased prevalence of it. Pathophysiological link between obesity, humoral adipokines and cytokines released from fat tissue and childhood-onset autoimmune rheumatic diseases is complex and still not entirely clear. From the clinical point of view, obesity was not associated with disease activity in JIA and cSLE, but proved to contribute on functional impairment in both diseases and affect poor treatment response in JIA patients. Early atherosclerosis and cardiovascular disease (CVD) development in obese children and adolescents with JIA, cSLE and JDM are certainly important obesity-related complications. Understanding how obesity affects children and adolescents with autoimmune rheumatic diseases may encourage clinicians to consider taking better preventive strategies in this population to improve their long-term outcome.
(© 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
Databáze: MEDLINE
Externí odkaz: