The I.3.2 developmental mutant has a single nucleotide deletion in the gene centromere identifier .

Autor:	Evans CJ; Department of Biology, Loyola Marymount University, Los Angeles, CA, USA., Bieser KL; Department of Physical and Life Sciences, Nevada State College, Henderson, NV, USA., Acevedo-Vasquez KS; Department of Physical and Life Sciences, Nevada State College, Henderson, NV, USA., Augustine EJ; Department of Physical and Life Sciences, Nevada State College, Henderson, NV, USA., Bowen S; Department of Physical and Life Sciences, Nevada State College, Henderson, NV, USA., Casarez VA; Department of Biology, Loyola Marymount University, Los Angeles, CA, USA., Feliciano VI; Department of Physical and Life Sciences, Nevada State College, Henderson, NV, USA., Glazier A; Department of Biology, Loyola Marymount University, Los Angeles, CA, USA., Guinan HR; Department of Biology, Loyola Marymount University, Los Angeles, CA, USA., Hallman R; Department of Physical and Life Sciences, Nevada State College, Henderson, NV, USA., Haugan E; Department of Biology, Loyola Marymount University, Los Angeles, CA, USA., Hehr LA; Department of Biology, Loyola Marymount University, Los Angeles, CA, USA., Hunnicutt SN; Department of Physical and Life Sciences, Nevada State College, Henderson, NV, USA., Leifer I; Department of Biology, Loyola Marymount University, Los Angeles, CA, USA., Mauger M; Department of Physical and Life Sciences, Nevada State College, Henderson, NV, USA., Mauger M; Department of Physical and Life Sciences, Nevada State College, Henderson, NV, USA., Melendez NY; Department of Physical and Life Sciences, Nevada State College, Henderson, NV, USA., Milshteyn L; Department of Biology, Loyola Marymount University, Los Angeles, CA, USA., Moore E; Department of Physical and Life Sciences, Nevada State College, Henderson, NV, USA., Nguyen SA; Department of Biology, Loyola Marymount University, Los Angeles, CA, USA., Phanphouvong SC; Department of Physical and Life Sciences, Nevada State College, Henderson, NV, USA., Pinal DM; Department of Physical and Life Sciences, Nevada State College, Henderson, NV, USA., Pope HM; Department of Physical and Life Sciences, Nevada State College, Henderson, NV, USA., Salinas MM; Department of Biology, Loyola Marymount University, Los Angeles, CA, USA., Shellin M; Department of Biology, Loyola Marymount University, Los Angeles, CA, USA., Small I; Department of Biology, Loyola Marymount University, Los Angeles, CA, USA., Yeoh NC; Department of Biology, Loyola Marymount University, Los Angeles, CA, USA., Yokomizo AMK; Department of Physical and Life Sciences, Nevada State College, Henderson, NV, USA., Kagey JD; Biology Department, University of Detroit Mercy, Detroit, MI, USA.
Jazyk:	angličtina
Zdroj:	MicroPublication biology [MicroPubl Biol] 2022 Oct 25; Vol. 2022. Date of Electronic Publication: 2022 Oct 25 (Print Publication: 2022).
DOI:	10.17912/micropub.biology.000653
Abstrakt:	The mutation I.3.2 was previously identified in a FLP/FRT screen of chromosome 2R for conditional growth regulators. Here we report the phenotypic characterization and genetic mapping of I.3.2 by undergraduate students participating in Fly-CURE, a pedagogical program that teaches the science of genetics through a classroom research experience. We find that creation of I.3.2 cell clones in the developing eye-antennal imaginal disc causes a headless adult phenotype, suggestive of both autonomous and non-autonomous effects on cell growth or viability. We also identify the I.3.2 mutation as a loss-of-function allele of the gene centromere identifier ( cid ), which encodes centromere-specific histone H3 variant critical for chromosomal segregation. (Copyright: © 2022 by the authors.)
Databáze:	MEDLINE
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