Effective Treatment of Chronic Cough with Tinidazole as the Newest Antiprotozoa against Lophomonas blattarum .

Autor: Anhaee Nasseri Z; Department of Internal Medicine, Faculty of Medicine, Islamic Azad University, Mashhad Branch, Mashhad, Iran., Mirsadraee M; Clinical Professor, Internist and Pulmonologist, Department of Internal Medicine, Medical School of Islamic Azad University, Mashhad Medical Sciences Branch, Mashhad, Iran., Manafi Varkiani M; Department of Internal Medicine, Faculty of Medicine, Islamic Azad University, Mashhad Branch, Mashhad, Iran., Ghaderi Y; Resident in Cardiology, Department of Cardiology, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran., Berenji F; Department of Parasitology, Mashhad University of Medical Sciences, Mashhad, Iran., Ghaffari S; Department of Physiology, Faculty of Biology, Islamic Azad University, Damghan, Iran.
Jazyk: angličtina
Zdroj: Journal of parasitology research [J Parasitol Res] 2022 Nov 03; Vol. 2022, pp. 2413941. Date of Electronic Publication: 2022 Nov 03 (Print Publication: 2022).
DOI: 10.1155/2022/2413941
Abstrakt: Background: Chronic cough is a common problem in the setting of family physicians. Recently, Lophomonas blattarum was considered a cause of respiratory symptoms in children and adults.
Objective: This study is aimed at determining the effect of antiprotozoal treatment of Lophomonas in patients with a chronic cough in Mashhad during 2020-2021.
Materials and Methods: This study was a randomized clinical trial. In this study, 60 patients with chronic cough and unremarkable imaging findings, who were unresponsive to three steps of standard treatment, were randomly assigned to the treatment, with 2 weeks of tinidazole and placebo. The tinidazole and placebo were prepared in a completely identical shape, and a random assignment was performed by a third party. The primary outcome was a complete resolution of cough. A follow-up of treatment was performed. Data were analyzed using the SPSS software version 25.
Results: The basic demographic results showed no significant differences of sex and age between two groups. The results of this study showed a complete resolution of all respiratory symptoms in 40% (12), a complete improvement of cough in 40% (12), and a complete resolution of dyspnea in 50% (10) of the tinidazole group. The remaining showed significant improvement in the severity of cough and dyspnea. Postnasal drip, sputum, body temperature, and airway hyperresponsiveness were improved significantly. After tinidazole treatment, laboratory assessment of bronchial lavage and sputum revealed that 86 percent of smears were converted to negative.
Conclusion: Tinidazole effectively resolved the chronic cough and most of the respiratory symptoms. Lophomonas blattarum is a potential mechanism for chronic cough.
Competing Interests: The authors of the present study declare that there are no financial conflicts of interest to disclose.
(Copyright © 2022 Zahra Anhaee Nasseri et al.)
Databáze: MEDLINE
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