New Insights into Melanoma Tumor Syndromes.
| Autor: | Rashid S; Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.; Boston University School of Medicine, Boston, Massachusetts, USA., Gupta S; Department of Dermatology, The Warren Alpert Medical School, Brown University, Providence, Rhode Island, USA., McCormick SR; Mass General Cancer Center, Massachusetts General Hospital, Boston, Massachusetts, USA., Tsao H; Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.; Department of Dermatology, Massachusetts General Hospital, Boston, Massachusetts, USA. |
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| Jazyk: | angličtina |
| Zdroj: | JID innovations : skin science from molecules to population health [JID Innov] 2022 Sep 02; Vol. 2 (6), pp. 100152. Date of Electronic Publication: 2022 Sep 02 (Print Publication: 2022). |
| DOI: | 10.1016/j.xjidi.2022.100152 |
| Abstrakt: | Melanoma tumor syndromes (MTS) represent an important minority of familial melanoma cases. In these patients, the accumulation of sequence alterations in essential genes may prelude the risk of internal malignancies, in addition to melanoma. Although several host and environmental factors have been implicated in familial melanoma, the exact mechanisms of cancer predisposition-particularly in the context of mixed cancer syndromes-still remain unclear. In this paper, we review new insights into MTS and elucidate recent efforts that guide individualized prognostication and treatment for these diseases in the past quarter century. (© 2022 The Authors.) |
| Databáze: | MEDLINE |
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