ALASCA: An R package for longitudinal and cross-sectional analysis of multivariate data by ASCA-based methods.
| Autor: | Jarmund AH; Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.; Centre of Molecular Inflammation Research (CEMIR), NTNU, Trondheim, Norway., Madssen TS; Department of Circulation and Medical Imaging, NTNU, Trondheim, Norway., Giskeødegård GF; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Trondheim, Norway. |
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| Jazyk: | angličtina |
| Zdroj: | Frontiers in molecular biosciences [Front Mol Biosci] 2022 Oct 26; Vol. 9, pp. 962431. Date of Electronic Publication: 2022 Oct 26 (Print Publication: 2022). |
| DOI: | 10.3389/fmolb.2022.962431 |
| Abstrakt: | The increasing availability of multivariate data within biomedical research calls for appropriate statistical methods that can describe and model complex relationships between variables. The extended ANOVA simultaneous component analysis (ASCA + ) framework combines general linear models and principal component analysis (PCA) to decompose and visualize the separate effects of experimental factors. It has recently been demonstrated how linear mixed models can be included in the framework to analyze data from longitudinal experimental designs with repeated measurements (RM-ASCA + ). The ALASCA package for R makes the ASCA + framework accessible for general use and includes multiple methods for validation and visualization. The package is especially useful for longitudinal data and the ability to easily adjust for covariates is an important strength. This paper demonstrates how the ALASCA package can be applied to gain insights into multivariate data from interventional as well as observational designs. Publicly available data sets from four studies are used to demonstrate the methods available (proteomics, metabolomics, and transcriptomics). Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2022 Jarmund, Madssen and Giskeødegård.) |
| Databáze: | MEDLINE |
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