Duration of Diabetes, Glycemic Control, and Risk of Heart Failure Among Adults With Diabetes: A Cohort Study.

Autor:	Yang HH; Vanke School of Public Health, Tsinghua University, Beijing 100084, China., Li FR; Shenzhen Key Laboratory of Cardiovascular Health and Precision Medicine, Southern University of Science and Technology, Shenzhen 518055, China.; School of Public Health and Emergency Management, Southern University of Science and Technology, Shenzhen 518055, China., Chen ZK; Vanke School of Public Health, Tsinghua University, Beijing 100084, China., Zhou MG; Vanke School of Public Health, Tsinghua University, Beijing 100084, China., Xie LF; Vanke School of Public Health, Tsinghua University, Beijing 100084, China.; School of Human Nutrition, McGill University, Sainte-Anne-de-Bellevue, Quebec H9X 3V9, Canada., Jin YY; Vanke School of Public Health, Tsinghua University, Beijing 100084, China.; School of Nursing, University of Wisconsin-Madison, Madison, Wisconsin 53705, USA., Li ZH; Vanke School of Public Health, Tsinghua University, Beijing 100084, China., Chen GC; Department of Nutrition and Food Hygiene, School of Public Health, Suzhou Medical College of Soochow University, Suzhou 215123, Jiangsu, China.
Jazyk:	angličtina
Zdroj:	The Journal of clinical endocrinology and metabolism [J Clin Endocrinol Metab] 2023 Apr 13; Vol. 108 (5), pp. 1166-1172.
DOI:	10.1210/clinem/dgac642
Abstrakt:	Context: The influences of diabetes duration and glycemic control and their potential interplays on the risk of heart failure (HF) remain unclear. Objective: This work aimed to investigate the association of diabetes duration and glycemic control with the risk of HF. Methods: A total of 23 754 individuals with diabetes but without HF during the baseline recruitment of UK Biobank were included in this study. Duration of diabetes was self-reported, and the status of glycemic control was reflected by glycated hemoglobin A1c (HbA1c) levels. Their associations with incident HF were assessed using multivariate Cox models adjusting for traditional risk factors. Results: Duration of diabetes and HbA1c levels both were positively associated with the risk of HF. The hazard ratios (HRs) (95% CI) for diabetes durations of 5 to less than 10, 10 to less than 15, and 15 years or more were 1.09 (0.97-1.23), 1.13 (0.97-1.30), and 1.32 (1.15-1.53), respectively (vs < 5 years); and the HRs for HbA1c of 53.0 to less than 58.5 mmol/mol (7.0% to < 7.5%), 58.5 to less than 63.9 mmol/mol (7.5% to < 8.0%), and 63.9 mmol/mol or greater (8.0%) were 1.15 (1.02-1.31), 1.07 (0.91-1.26), and 1.46 (1.30-1.65), respectively (vs < 53.0 mmol/mol [7.0%]). Individuals with the longest disease duration (≥ 15 years) and poorer glycemic control (HbA1c ≥ 63.9 mmol/mol [8.0%]) had a particularly higher risk of HF (P for interaction = .026). Conclusion: The risk of HF among individuals with diabetes increases with a longer duration of diabetes and increasing HbA1c levels. This finding may contribute to the individualized prevention of HF in patients with diabetes if being considered in clinical practices and policy-making. (© The Author(s) 2022. Published by Oxford University Press on behalf of the Endocrine Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
Databáze:	MEDLINE
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