Resin-modified glass ionomer enriched with BIOGLASS: Ion-release, bioactivity and antibacterial effect.

Autor: de Oliveira Roma FRV; Laboratório de Biomateriais em Odontologia (Biomma), Departamento de Odontologia I, Universidade Federal do Maranhão (UFMA), São Luís, Maranhão, Brazil., de Oliveira TJL; Laboratório de Biomateriais em Odontologia (Biomma), Departamento de Odontologia I, Universidade Federal do Maranhão (UFMA), São Luís, Maranhão, Brazil., Bauer J; Laboratório de Biomateriais em Odontologia (Biomma), Departamento de Odontologia I, Universidade Federal do Maranhão (UFMA), São Luís, Maranhão, Brazil., Firoozmand LM; Laboratório de Biomateriais em Odontologia (Biomma), Departamento de Odontologia I, Universidade Federal do Maranhão (UFMA), São Luís, Maranhão, Brazil.
Jazyk: angličtina
Zdroj: Journal of biomedical materials research. Part B, Applied biomaterials [J Biomed Mater Res B Appl Biomater] 2023 Apr; Vol. 111 (4), pp. 903-911. Date of Electronic Publication: 2022 Nov 16.
DOI: 10.1002/jbm.b.35200
Abstrakt: Developing dental materials for the prevention of remineralization or demineralization is important for high-risk caries patients. This study aimed to evaluate the physicochemical and microbiological effects of adding 45S5 bioglass to resin-modified glass ionomer cement (RMGIC). Samples belonged to the following groups: GIC: conventional glass ionomer cement (Vitro Fil), RMGIC: resin-modified GIC (Vitro Fil LC), and RMGIC/45S5: RMGIC with 10% (wt %) of 45S5. Changes in pH and release of fluoride, calcium, and phosphorus ions under acidic (pH 4) and neutral (pH 7) pH conditions were evaluated. Antibacterial activity was verified based on colony-forming units. Material sorption and solubility were analyzed after bacterial exposure. After 28 days, the bioactivity of the materials was evaluated using scanning electron microscopy/energy dispersive X-ray spectroscopy (SEM/EDS). Analysis of variance, post hoc Scheffe, and Tukey (α = 0.05) tests were employed for statistical analysis. RMGIC/45S5 showed higher alkalization activity, calcium release at pH 4 and 7, and sorption than GIC and RMGIC (p < .05). Release of phosphorus and fluoride at pH 4 and 7 was higher for GIC than that for RMGIC and RMGIC/45S5 (p < .05). RMGIC/45S5 showed higher values than RMGIC (p < .05). However, antibacterial activity did not differ among the groups. Precipitates of calcium and phosphorus were visualized in RMGIC/45S5 samples via SEM/EDS. These results indicate that the RMGIC/45S5 promotes alkalization and increases the release of calcium, phosphorus, and fluoride ions, resulting in precipitate deposition rich in calcium and phosphorus, thereby being a promising option to improve the bioactivity of RMGIC.
(© 2022 Wiley Periodicals LLC.)
Databáze: MEDLINE
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