Clinical characteristics, management, and quality of life of psoriasis patients with coexistent lupus erythematosus: Data from the Malaysian Psoriasis Registry.

Autor: Gan TS; Department of Dermatology, Hospital Kuala Lumpur, Kuala Lumpur, Malaysia., Ghazali NI; Department of Dermatology, Hospital Kuala Lumpur, Kuala Lumpur, Malaysia., Voo SYM; Department of Dermatology, Hospital Queen Elizabeth, Kota Kinabalu, Malaysia., Low DE; Department of Dermatology, Hospital Serdang, Kajang, Malaysia., Tang JJ; Department of Dermatology, Hospital Raja Permaisuri Bainun, Ipoh, Malaysia., Kiing JW; Department of Dermatology, Hospital Umum Sarawak, Kuching, Malaysia., Muniandy P; Department of Dermatology, Hospital Umum Sarawak, Kuching, Malaysia., Tey KE; Department of Dermatology, Hospital Sultanah Aminah, Johor Bahru, Malaysia., Wong KW; Department of Dermatology, Hospital Sultanah Aminah, Johor Bahru, Malaysia., Mohamad N; Department of Dermatology, Hospital Sultanah Nur Zahirah, Kuala Terengganu, Malaysia., Tan WC; Department of Dermatology, Hospital Pulau Pinang, Georgetown, Malaysia., Selvarajah L; Department of Dermatology, Hospital Sultan Ismail, Johor Bharu, Malaysia., Ramalingam R; Department of Dermatology, Hospital Tengku Ampuan Afzan, Kuantan, Malaysia., Ng FY; Department of Dermatology, Hospital Tengku Ampuan Rahimah, Klang, Malaysia., Lee CS; Department of Dermatology, Hospital Melaka, Melaka, Malaysia., Raja T; Department of Dermatology, Hospital Selayang, Batu Caves, Malaysia., Abdul Rahim NS; Department of Dermatology, Hospital Putrajaya, Putrajaya, Malaysia., Tang MM; Department of Dermatology, Hospital Kuala Lumpur, Kuala Lumpur, Malaysia., Robinson S; Department of Dermatology, Hospital Kuala Lumpur, Kuala Lumpur, Malaysia.
Jazyk: angličtina
Zdroj: International journal of rheumatic diseases [Int J Rheum Dis] 2023 Feb; Vol. 26 (2), pp. 327-336. Date of Electronic Publication: 2022 Nov 16.
DOI: 10.1111/1756-185X.14492
Abstrakt: Objective: To describe the clinical characteristics, management and quality of life of psoriasis patients with and without coexistent lupus erythematosus (LE).
Methods: This retrospective cross-sectional study uses data from the Malaysian Psoriasis Registry (MPR) from January 2007 to December 2018.
Results: Of 21 735 psoriasis patients, 34 (0.16%) had coexistent LE. The male to female ratio among psoriasis patients with coexistent LE was 1:5.8 versus 1.3:1 in patients with psoriasis but without LE. Nearly 70% presented with LE preceding psoriasis. Psoriasis patients with LE had an earlier age of psoriasis onset (27.56 ± 11.51 versus 33.31 ± 16.94 years, P = 0.006), a higher rate of psoriatic arthropathy (26.5% versus 13.0%, P = 0.02), and a significantly greater impairment of quality of life (Dermatology Quality of Life Index >10; 57.6% versus 40.3%, P = 0.04) compared with psoriasis patients without LE. The majority (87.5%) had systemic LE. The incidences of lupus nephritis (72.7% versus 40%) and hematological abnormalities (50% versus 20%) were higher among patients with LE preceding psoriasis compared with those with psoriasis preceding LE. Antinuclear antibody and double-stranded DNA were positive in 59.4% and 28.1% of psoriasis patients with LE, respectively. Hydroxychloroquine triggered the onset of psoriasis in 7 (24.1%) patients. Patients with LE were more likely to receive systemic treatment for psoriasis compared with those without LE (30.3% versus 14.2%, P = 0.008).
Conclusions: Psoriasis patients with coexistent LE were uncommon, displayed a female preponderance, were more likely to have joint involvement, and had greater quality of life impairment than those without LE. LE preceded psoriasis in most of these patients, and systemic LE was the most common subtype.
(© 2022 Asia Pacific League of Associations for Rheumatology and John Wiley & Sons Australia, Ltd.)
Databáze: MEDLINE
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