Mitochondrial DNA: Consensuses and Controversies.
| Autor: | Shokolenko I; Department of Biomedical Sciences, Pat Capps Covey College of Allied Health Professions, University of South Alabama, Mobile, AL 36688, USA., Alexeyev M; Department of Physiology and Cell Biology, University of South Alabama, Mobile, AL 36688, USA. |
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| Jazyk: | angličtina |
| Zdroj: | DNA [DNA (Basel)] 2022 Jun; Vol. 2 (2), pp. 131-148. Date of Electronic Publication: 2022 Jun 10. |
| DOI: | 10.3390/dna2020010 |
| Abstrakt: | In the course of its short history, mitochondrial DNA (mtDNA) has made a long journey from obscurity to the forefront of research on major biological processes. mtDNA alterations have been found in all major disease groups, and their significance remains the subject of intense research. Despite remarkable progress, our understanding of the major aspects of mtDNA biology, such as its replication, damage, repair, transcription, maintenance, etc., is frustratingly limited. The path to better understanding mtDNA and its role in cells, however, remains torturous and not without errors, which sometimes leave a long trail of controversy behind them. This review aims to provide a brief summary of our current knowledge of mtDNA and highlight some of the controversies that require attention from the mitochondrial research community. Competing Interests: Conflicts of Interest: The authors declare no conflict of interest. |
| Databáze: | MEDLINE |
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