Evaluation of amino acid profile in serum of patients with Covid-19 for providing a new treatment strategy.
| Autor: | Ozturk A; Niğde Omer Halisdemir University, Faculty of Medicine, Department of Medical Microbiology, Niğde, Turkey., Bayraktar N; Harran University, Faculty of Medicine, Department of Medical Biochemistry, Şanlıurfa, Turkey., Bayraktar M; Yıdırım Beyazıt University, Faculty of Medicine, Department of Internal Medical, Ankara, Turkey., Ibrahim B; Suleyman Demirel Universit, Faculty of Pharmacy Department of Pharmaceutical Microbiology, Isparta, Turkey., Bozok T; Mersin University, Faculty of Medicine, Department of Medical Microbiology, Mersin, Turkey., Resat CM; Harran University, Faculty of Medicine, Department of Infectious Diseases, Şanlıurfa, Turkey. |
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| Jazyk: | angličtina |
| Zdroj: | Journal of medical biochemistry [J Med Biochem] 2022 Oct 15; Vol. 41 (4), pp. 526-533. |
| DOI: | 10.5937/jomb0-37514 |
| Abstrakt: | Background: Amino acids have an important role in metabolism and may affect COVID-19-related outcomes. In our study, the amino acid serum level of hospitalized COVID19 patients was evaluated to determine a new treatment strategy. Methods: The amino acid profile covering 43 amino acids in 68 subjects, comprising 30 (14 men and 16 women) controls and 38 (16 men and 22 women) COVID-19 patients, were examined. The amino acid profiles of the participants were screened by LC-MS/MS. Results: Compared with the control group, serum levels of 27 amino acids increased in the patient group. Alpha-aminopimelic acid, sarcosine, and hydroxyproline amino acids were considerably higher in the control group than in the patient group (p<0.0001). There was no notable difference among control group and the case group for 13 amino acids (p≥0.05). A significant positive correlation was seen among the control and the patient groups in the mean amino acid values (r=0.937; p<0.0001). Conclusions: These results postulated a clear picture on the serum levels of amino acid in the COVID-19 patients. Serum amino acids measured in hospitalized COVID-19 patients can explain the patient's metabolic status during the disease. Competing Interests: Conflict of Interest: The authors stated that they have no conflicts of interest regarding the publication of this article. (2022 Ali Ozturk, Nihayet Bayraktar, Mustafa Bayraktar, Bashar Ibrahim, Taylan Bozok, Ceylan Mehmet Resat, published by CEON/CEES.) |
| Databáze: | MEDLINE |
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