Fluorene intercalated graphene oxide based CoQ10 imprinted polymer composite as a selective platform for electrochemical sensing of CoQ10.

Autor:	Soomro AN; National Center of Excellence in Analytical Chemistry, University of Sindh Jamshoro-76080 Sindh Pakistan huma.hashu@gmail.com soomroanamnaz@gmail.com +92-022-2771560 +92-022-2771379., Shaikh H; National Center of Excellence in Analytical Chemistry, University of Sindh Jamshoro-76080 Sindh Pakistan huma.hashu@gmail.com soomroanamnaz@gmail.com +92-022-2771560 +92-022-2771379., Malik MI; H. E. J. Research Institute of Chemistry, International Centre for Chemical and Biological Sciences (ICCBS), University of Karachi Karachi-75270 Sindh Pakistan mimran.malik@iccs.edu., Buledi JA; National Center of Excellence in Analytical Chemistry, University of Sindh Jamshoro-76080 Sindh Pakistan huma.hashu@gmail.com soomroanamnaz@gmail.com +92-022-2771560 +92-022-2771379., Qazi S; National Center of Excellence in Analytical Chemistry, University of Sindh Jamshoro-76080 Sindh Pakistan huma.hashu@gmail.com soomroanamnaz@gmail.com +92-022-2771560 +92-022-2771379., Solangi A; National Center of Excellence in Analytical Chemistry, University of Sindh Jamshoro-76080 Sindh Pakistan huma.hashu@gmail.com soomroanamnaz@gmail.com +92-022-2771560 +92-022-2771379.
Jazyk:	angličtina
Zdroj:	RSC advances [RSC Adv] 2022 Nov 04; Vol. 12 (49), pp. 31639-31649. Date of Electronic Publication: 2022 Nov 04 (Print Publication: 2022).
DOI:	10.1039/d2ra05401a
Abstrakt:	The new objective of sustainable analytical chemistry is to develop validated robust, swift, simple and highly sensitive analytical methods that are based on cost effective sensing technology. Therefore, in this study the electro-chemical detection of coenzyme Q10 (CoQ10) was achieved using a fluorene intercalated graphene oxide based CoQ10 imprinted polymer composite modified glassy carbon electrode (CoQ10-IGOPC/GCE). The synthesized sensing material was characterized using SEM, XRD and FT-IR to determine the morphology and functional properties. The CoQ10-IGOPC/GCE was characterized by EIS for its electrochemical properties. CoQ10 was detected selectively using Differential Pulse Voltammetry (DPV). Under ideal circumstances, a linear calibration curve with a correlation coefficient ( R 2 ) of 0.991 was produced in the concentration range of 0.0967 to 28.7 μM. The limit of detection (LOD) and limit of quantification (LOQ) were found to be 0.029 and 0.0967 μM, respectively. Furthermore, the proposed electrochemical sensor was extremely selective, accurate and thoroughly validated with RSD values less than 5%. The developed CoQ10-IGOPC/GCE based electrochemical sensor was successfully used for the detection of CoQ10 in samples of fruits, vegetables, nuts, human blood serum and pharmaceuticals. The CoQ10-IGOPC/GCE based electrochemical method showed good percent recoveries ranging from 94 to 103 percent. Competing Interests: All the authors of this manuscript confirm that there is no conflict of interest. (This journal is © The Royal Society of Chemistry.)
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