Independent effects of acute normobaric hypoxia and hypobaric hypoxia on human physiology.

Autor: Rosales AM; School of Health and Kinesiology, University of Nebraska at Omaha, Omaha, NE, USA.; Montana Center for Work Physiology and Exercise Metabolism, Department of Integrative Physiology and Athletic Training, University of Montana, 32 Campus Drive, McGill Hall, Missoula, MT, 59812, USA., Shute RJ; School of Health and Kinesiology, University of Nebraska at Omaha, Omaha, NE, USA., Hailes WS; Montana Center for Work Physiology and Exercise Metabolism, Department of Integrative Physiology and Athletic Training, University of Montana, 32 Campus Drive, McGill Hall, Missoula, MT, 59812, USA., Collins CW; School of Health and Kinesiology, University of Nebraska at Omaha, Omaha, NE, USA., Ruby BC; Montana Center for Work Physiology and Exercise Metabolism, Department of Integrative Physiology and Athletic Training, University of Montana, 32 Campus Drive, McGill Hall, Missoula, MT, 59812, USA., Slivka DR; School of Health and Kinesiology, University of Nebraska at Omaha, Omaha, NE, USA. dustin.slivka@mso.umt.edu.; Montana Center for Work Physiology and Exercise Metabolism, Department of Integrative Physiology and Athletic Training, University of Montana, 32 Campus Drive, McGill Hall, Missoula, MT, 59812, USA. dustin.slivka@mso.umt.edu.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2022 Nov 15; Vol. 12 (1), pp. 19570. Date of Electronic Publication: 2022 Nov 15.
DOI: 10.1038/s41598-022-23698-5
Abstrakt: The purpose of this study was to examine the effects of acute normobaric (NH, decreased FiO 2 ) and hypobaric (HH, 4200 m ascent) hypoxia exposures compared to sea level (normobaric normoxia, NN). Tissue oxygenation, cardiovascular, and body fluid variables measured during rest and a 3-min step-test following 90-min exposures (NH, HH, NN). Muscle oxygenated hemoglobin (O 2 Hb) decreased, and muscle deoxygenated hemoglobin (HHb) increased environmentally independent from rest to exercise (p < 0.001). During exercise, brain O 2 Hb was lower at HH compared to NN (p = 0.007), trending similarly with NH (p = 0.066), but no difference between NN and NH (p = 0.158). During exercise, HR at NH (141 ± 4 beats·min -1 ) and HH (141 ± 3 beats·min -1 ) were higher than NN (127 ± 44 beats·min -1 , p = 0.002), but not each other (p = 0.208). During exercise, stroke volume at HH (109.6 ± 4.1 mL·beat -1 ) was higher than NH (97.8 ± 3.3 mL·beat -1 ) and NN (99.8 ± 3.9 mL·beat -1 , p ≤ 0.010) with no difference between NH and NN (p = 0.481). During exercise, cardiac output at NH (13.8 ± 0.6 L) and HH (15.5 ± 0.7 L) were higher than NN (12.6 ± 0.5 L, p ≤ 0.006) with HH also higher than NH (p = 0.001). During acute hypoxic stimuli, skeletal muscle maintains oxygenation whereas the brain does not. These differences may be mediated by environmentally specific cardiovascular compensation. Thus, caution is advised when equating NH and HH.
(© 2022. The Author(s).)
Databáze: MEDLINE
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