Restricted cafeteria feeding and treadmill exercise improved body composition, metabolic profile and exploratory behavior in obese male rats.

Autor: Alvarez-Monell A; Medical Physiology Unit, Department of Cell Biology, Physiology and Immunology, Faculty of Medicine, Universitat Autònoma de Barcelona, 08193, Bellaterra, Spain.; Institut de Neurociències, Universitat Autònoma de Barcelona, 08193, Bellaterra, Spain., Subias-Gusils A; Institut de Neurociències, Universitat Autònoma de Barcelona, 08193, Bellaterra, Spain.; Unitat de Psicologia Mèdica, Departament de Psiquiatria i Medicina Legal, Universitat Autònoma de Barcelona, 08193, Bellaterra, Spain., Mariné-Casadó R; Eurecat, Centre Tecnològic de Catalunya, Biotechnology Area and Technological Unit of Nutrition and Health, 43204, Reus, Spain., Belda X; Institut de Neurociències, Universitat Autònoma de Barcelona, 08193, Bellaterra, Spain.; Animal Physiology Unit, Department of Cell Biology, Physiology and Immunology, Faculty of Biosciences, Universitat Autònoma de Barcelona, 08193, Bellaterra, Spain., Gagliano H; Institut de Neurociències, Universitat Autònoma de Barcelona, 08193, Bellaterra, Spain.; Animal Physiology Unit, Department of Cell Biology, Physiology and Immunology, Faculty of Biosciences, Universitat Autònoma de Barcelona, 08193, Bellaterra, Spain., Pozo OJ; Gastroesophageal Carcinogenesis Group, IMIM (Hospital del Mar Medical Research Institute), Carrer Doctor Aiguader 88, 08003, Barcelona, Spain., Boqué N; Eurecat, Centre Tecnològic de Catalunya, Biotechnology Area and Technological Unit of Nutrition and Health, 43204, Reus, Spain., Caimari A; Eurecat, Centre Tecnològic de Catalunya, Biotechnology Area and Technological Unit of Nutrition and Health, 43204, Reus, Spain., Armario A; Institut de Neurociències, Universitat Autònoma de Barcelona, 08193, Bellaterra, Spain.; Animal Physiology Unit, Department of Cell Biology, Physiology and Immunology, Faculty of Biosciences, Universitat Autònoma de Barcelona, 08193, Bellaterra, Spain., Solanas M; Medical Physiology Unit, Department of Cell Biology, Physiology and Immunology, Faculty of Medicine, Universitat Autònoma de Barcelona, 08193, Bellaterra, Spain. Montserrat.Solanas@uab.cat.; Institut de Neurociències, Universitat Autònoma de Barcelona, 08193, Bellaterra, Spain. Montserrat.Solanas@uab.cat., Escorihuela RM; Institut de Neurociències, Universitat Autònoma de Barcelona, 08193, Bellaterra, Spain. Rosamaria.Escorihuela@uab.cat.; Animal Physiology Unit, Department of Cell Biology, Physiology and Immunology, Faculty of Biosciences, Universitat Autònoma de Barcelona, 08193, Bellaterra, Spain. Rosamaria.Escorihuela@uab.cat.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2022 Nov 15; Vol. 12 (1), pp. 19545. Date of Electronic Publication: 2022 Nov 15.
DOI: 10.1038/s41598-022-23464-7
Abstrakt: The aim of this study was to evaluate, in male Long-Evans rats, whether a restricted-cafeteria diet (CAFR), based on a 30% calorie restriction vs continuous ad libitum cafeteria (CAF) fed animals, administered alone or in combination with moderate treadmill exercise (12 m/min, 35 min, 5 days/week for 8 weeks), was able to ameliorate obesity and the associated risk factors induced by CAF feeding for 18 weeks and to examine the changes in circadian locomotor activity, hypothalamic-pituitary-adrenal (HPA) axis functionality, and stress response elicited by this dietary pattern. In addition to the expected increase in body weight and adiposity, and the development of metabolic dysregulations compatible with Metabolic Syndrome, CAF intake resulted in a sedentary profile assessed by the home-cage activity test, reduced baseline HPA axis activity through decreased corticosterone levels, and boosted exploratory behavior. Both CAFR alone and in combination with exercise reduced abdominal adiposity and hypercholesterolemia compared to CAF. Exercise increased baseline locomotor activity in the home-cage in all dietary groups, boosted exploratory behavior in STD and CAF, partially decreased anxiety-like behavior in CAF and CAFR, but did not affect HPA axis-related parameters.
(© 2022. The Author(s).)
Databáze: MEDLINE
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