Enterovirus detection in stool samples from Mozambican children with acute gastroenteritis.

Autor: Bero DM; Instituto Nacional de Saúde, Vila de Marracuene, EN1, Parcela N° 3943, Província de Maputo, Moçambique. Electronic address: diocreciano.bero@ins.gov.mz., da Silva EE; Enterovirus Laboratory, Oswaldo Cruz Institute, Avenida Brasil 4365, Manguinhos, Rio de Janeiro, RJ CEP 21040-360, Brazil., Júnior IPS; Enterovirus Laboratory, Oswaldo Cruz Institute, Avenida Brasil 4365, Manguinhos, Rio de Janeiro, RJ CEP 21040-360, Brazil., Nhassengo SA; Instituto Nacional de Saúde, Vila de Marracuene, EN1, Parcela N° 3943, Província de Maputo, Moçambique., Machado RS; Enterovirus Laboratory, Oswaldo Cruz Institute, Avenida Brasil 4365, Manguinhos, Rio de Janeiro, RJ CEP 21040-360, Brazil., Bauhofer AFL; Instituto Nacional de Saúde, Vila de Marracuene, EN1, Parcela N° 3943, Província de Maputo, Moçambique; Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, Lisboa, Portugal., Chilaúle JJ; Instituto Nacional de Saúde, Vila de Marracuene, EN1, Parcela N° 3943, Província de Maputo, Moçambique., Munlela B; Instituto Nacional de Saúde, Vila de Marracuene, EN1, Parcela N° 3943, Província de Maputo, Moçambique., Guimarães E; Instituto Nacional de Saúde, Vila de Marracuene, EN1, Parcela N° 3943, Província de Maputo, Moçambique; Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, Lisboa, Portugal., Cossa-Moiane I; Instituto Nacional de Saúde, Vila de Marracuene, EN1, Parcela N° 3943, Província de Maputo, Moçambique; Institute of Tropical Medicine, Antwerp, Belgium., Sambo J; Instituto Nacional de Saúde, Vila de Marracuene, EN1, Parcela N° 3943, Província de Maputo, Moçambique; Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, Lisboa, Portugal., Anapakala E; Instituto Nacional de Saúde, Vila de Marracuene, EN1, Parcela N° 3943, Província de Maputo, Moçambique., Cassocera M; Instituto Nacional de Saúde, Vila de Marracuene, EN1, Parcela N° 3943, Província de Maputo, Moçambique; Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, Lisboa, Portugal., Coutinho-Manhique L; Instituto Nacional de Saúde, Vila de Marracuene, EN1, Parcela N° 3943, Província de Maputo, Moçambique., Chissaque A; Instituto Nacional de Saúde, Vila de Marracuene, EN1, Parcela N° 3943, Província de Maputo, Moçambique; Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, Lisboa, Portugal., Langa JS; Instituto Nacional de Saúde, Vila de Marracuene, EN1, Parcela N° 3943, Província de Maputo, Moçambique., Burlandy F; Enterovirus Laboratory, Oswaldo Cruz Institute, Avenida Brasil 4365, Manguinhos, Rio de Janeiro, RJ CEP 21040-360, Brazil., de Deus N; Instituto Nacional de Saúde, Vila de Marracuene, EN1, Parcela N° 3943, Província de Maputo, Moçambique.
Jazyk: angličtina
Zdroj: Acta tropica [Acta Trop] 2023 Feb; Vol. 238, pp. 106755. Date of Electronic Publication: 2022 Nov 12.
DOI: 10.1016/j.actatropica.2022.106755
Abstrakt: Enteroviruses (EV) are predominantly enteric viruses, present in all parts of the world causing disease in humans with a broad spectrum of clinical presentations. The purpose of this study was to identify non-polio enteroviruses (NPEV) in stool samples collected from children with acute gastroenteritis (AGE) symptoms of unknown etiology in four provinces (Maputo, Nampula, Sofala and Zambézia) of Mozambique. From June 2014 to March 2018, 327 stool samples were collected from children hospitalized with AGE in health care units. NPEVs were detected in 52 samples (52/327; 15.9%) and were more frequent in children under 5 years of age. The age group from 12 to 23 months was the most affected and showed more severity of disease. We also identified 26 different EV-types with the following detection pattern EV-B>EV-C>EV-A. The major EV-types were EV-A119 (9/52; 17.3%) and EV-C99 (8/52; 15.4%), accounting for 32.7% of the total. In addition to EV-A119, other uncommon EV-types were also identified, such as EV-B75, EV-B97 and EV-C113. The current study shows a high heterogeneity of EV types circulating in children with AGE in Mozambique as well as the identification of rarely described enteroviruses.
Competing Interests: Declaration of competing interest All authors have declared no conflict of interest.
(Copyright © 2022. Published by Elsevier B.V.)
Databáze: MEDLINE
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