Bipolar I and bipolar II subtypes in older age: Results from the Global Aging and Geriatric Experiments in Bipolar Disorder (GAGE-BD) project.

Autor: Beunders AJM; GGZ inGeest Specialized Mental Health Care, Old Age Psychiatry, Amsterdam, The Netherlands.; Amsterdam UMC location Vrije Universiteit Amsterdam, Psychiatry, Amsterdam, The Netherlands.; Amsterdam Public Health research institute, Mental Health, Amsterdam, The Netherlands., Klaus F; Department of Psychiatry, University of California San Diego, San Diego, California, USA.; Desert-Pacific Mental Illness Research Education and Clinical Center, VA San Diego Healthcare System, San Diego, USA., Kok AAL; GGZ inGeest Specialized Mental Health Care, Old Age Psychiatry, Amsterdam, The Netherlands.; Amsterdam UMC location Vrije Universiteit Amsterdam, Psychiatry, Amsterdam, The Netherlands.; Amsterdam Public Health research institute, Mental Health, Amsterdam, The Netherlands., Schouws SNTM; GGZ inGeest Specialized Mental Health Care, Old Age Psychiatry, Amsterdam, The Netherlands.; Amsterdam UMC location Vrije Universiteit Amsterdam, Psychiatry, Amsterdam, The Netherlands.; Amsterdam Public Health research institute, Mental Health, Amsterdam, The Netherlands., Kupka RW; GGZ inGeest Specialized Mental Health Care, Old Age Psychiatry, Amsterdam, The Netherlands.; Amsterdam UMC location Vrije Universiteit Amsterdam, Psychiatry, Amsterdam, The Netherlands.; Amsterdam Public Health research institute, Mental Health, Amsterdam, The Netherlands., Blumberg HP; Department of Psychiatry, Yale School of Medicine, New Haven, Connecticut, USA., Briggs F; Department of Population and Quantitative Health Sciences, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA., Eyler LT; Department of Psychiatry, University of California San Diego, San Diego, California, USA.; Desert-Pacific Mental Illness Research Education and Clinical Center, VA San Diego Healthcare System, San Diego, USA., Forester BP; Division of Geriatric Psychiatry, McLean Hospital, Belmont, Massachusetts, USA.; Harvard Medical School, Boston, Massachusetts, USA., Forlenza OV; Laboratory of Neuroscience (LIM27), Department and Institute of Psychiatry, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo HCFMUSP, São Paulo, Brazil., Gildengers A; Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA., Jimenez E; Bipolar and Depressive Disorders Unit, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Spain., Mulsant BH; Department of Psychiatry, Center for Addiction & Mental Health, University of Toronto, Toronto, Ontario, Canada., Patrick RE; Division of Geriatric Psychiatry, McLean Hospital, Belmont, Massachusetts, USA.; Harvard Medical School, Boston, Massachusetts, USA., Rej S; GeriPARTy Research Group, Jewish General Hospital/ Lady Davis Institute, Montreal, Quebec, Canada.; McGill University, Montreal, Quebec, Canada., Sajatovic M; Case Western Reserve University School of Medicine, University Hospitals Case Medical Center, Cleveland, Ohio, USA., Sarna K; Case Western Reserve University School of Medicine, University Hospitals Case Medical Center, Cleveland, Ohio, USA., Sutherland A; Department of Psychiatry, University of California San Diego, San Diego, California, USA.; Desert-Pacific Mental Illness Research Education and Clinical Center, VA San Diego Healthcare System, San Diego, USA., Yala J; Case Western Reserve University School of Medicine, University Hospitals Case Medical Center, Cleveland, Ohio, USA., Vieta E; Bipolar and Depressive Disorders Unit, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Spain., Villa LM; Department of Psychiatry, Yale School of Medicine, New Haven, Connecticut, USA.; Department of Psychiatry, University of Oxford, Oxford, UK., Korten NCM; GGZ inGeest Specialized Mental Health Care, Old Age Psychiatry, Amsterdam, The Netherlands.; Amsterdam UMC location Vrije Universiteit Amsterdam, Psychiatry, Amsterdam, The Netherlands.; Amsterdam Public Health research institute, Mental Health, Amsterdam, The Netherlands., Dols A; GGZ inGeest Specialized Mental Health Care, Old Age Psychiatry, Amsterdam, The Netherlands.; Amsterdam UMC location Vrije Universiteit Amsterdam, Psychiatry, Amsterdam, The Netherlands.; Amsterdam Public Health research institute, Mental Health, Amsterdam, The Netherlands.; Amsterdam Neuroscience, Neurodegeneration, Amsterdam, The Netherlands.; Department of Psychiatry, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht, The Netherlands.
Jazyk: angličtina
Zdroj: Bipolar disorders [Bipolar Disord] 2023 Feb; Vol. 25 (1), pp. 43-55. Date of Electronic Publication: 2022 Nov 23.
DOI: 10.1111/bdi.13271
Abstrakt: Objectives: The distinction between bipolar I disorder (BD-I) and bipolar II disorder (BD-II) has been a topic of long-lasting debate. This study examined differences between BD-I and BD-II in a large, global sample of OABD, focusing on general functioning, cognition and somatic burden as these domains are often affected in OABD.
Methods: Cross-sectional analyses were conducted with data from the Global Aging and Geriatric Experiments in Bipolar Disorder (GAGE-BD) database. The sample included 963 participants aged ≥50 years (714 BD-I, 249 BD-II). Sociodemographic and clinical factors were compared between BD subtypes including adjustment for study cohort. Multivariable analyses were conducted with generalized linear mixed models (GLMMs) and estimated associations between BD subtype and (1) general functioning (GAF), (2) cognitive performance (g-score) and (3) somatic burden, with study cohort as random intercept.
Results: After adjustment for study cohort, BD-II patients more often had a late onset ≥50 years (p = 0.008) and more current severe depression (p = 0.041). BD-I patients were more likely to have a history of psychiatric hospitalization (p < 0.001) and current use of anti-psychotics (p = 0.003). Multivariable analyses showed that BD subtype was not related to GAF, cognitive g-score or somatic burden.
Conclusion: BD-I and BD-II patients did not differ in terms of general functioning, cognitive impairment or somatic burden. Some clinical differences were observed between the groups, which could be the consequence of diagnostic definitions. The distinction between BD-I and BD-II is not the best way to subtype OABD patients. Future research should investigate other disease specifiers in this population.
(© 2022 The Authors. Bipolar Disorders published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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