Recovery of systemic hyperinflammation in patients with severe SARS-CoV-2 infection.

Autor: Langnau C; Department of Cardiology and Angiology, Eberhard Karls University Tuebingen, University Hospital Tuebingen, Tuebingen, Germany., Janing H; Department of Cardiology and Angiology, Eberhard Karls University Tuebingen, University Hospital Tuebingen, Tuebingen, Germany., Kocaman H; Department of Cardiology and Angiology, Eberhard Karls University Tuebingen, University Hospital Tuebingen, Tuebingen, Germany., Gekeler S; Department of Cardiology and Angiology, Eberhard Karls University Tuebingen, University Hospital Tuebingen, Tuebingen, Germany., Günter M; Department of Hematology, Oncology, Clinical Immunology and Rheumatology, Eberhard Karls University Tuebingen, University Hospital Tuebingen, Tuebingen, Germany.; Department of Dendritic Cells in Infection and Cancer, German Cancer Research Centre, Heidelberg, Germany., Petersen-Uribe Á; Department of Cardiology and Angiology, Eberhard Karls University Tuebingen, University Hospital Tuebingen, Tuebingen, Germany., Jaeger P; Department of Cardiology and Angiology, Eberhard Karls University Tuebingen, University Hospital Tuebingen, Tuebingen, Germany., Koch B; Department of Cardiology and Angiology, Eberhard Karls University Tuebingen, University Hospital Tuebingen, Tuebingen, Germany., Kreisselmeier KP; Department of Cardiology and Angiology, Eberhard Karls University Tuebingen, University Hospital Tuebingen, Tuebingen, Germany., Castor T; Department of Cardiology and Angiology, Eberhard Karls University Tuebingen, University Hospital Tuebingen, Tuebingen, Germany., Rath D; Department of Cardiology and Angiology, Eberhard Karls University Tuebingen, University Hospital Tuebingen, Tuebingen, Germany., Gawaz MP; Department of Cardiology and Angiology, Eberhard Karls University Tuebingen, University Hospital Tuebingen, Tuebingen, Germany., Autenrieth SE; Department of Hematology, Oncology, Clinical Immunology and Rheumatology, Eberhard Karls University Tuebingen, University Hospital Tuebingen, Tuebingen, Germany.; Department of Dendritic Cells in Infection and Cancer, German Cancer Research Centre, Heidelberg, Germany., Mueller KAL; Department of Cardiology and Angiology, Eberhard Karls University Tuebingen, University Hospital Tuebingen, Tuebingen, Germany.
Jazyk: angličtina
Zdroj: Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals [Biomarkers] 2023 Feb; Vol. 28 (1), pp. 97-110. Date of Electronic Publication: 2022 Nov 23.
DOI: 10.1080/1354750X.2022.2148745
Abstrakt: Introduction: Patients with cardiovascular disease (CVD) and acute SARS-CoV-2 infection might show an altered immune response during COVID-19.
Material and Methods: Twenty-three patients with CVD and SARS-CoV-2 infection were prospectively enrolled and received a cardiological assessment at study entry and during follow-up visit. Inclusion criteria of our study were age older than 18 years, presence of CVD, and acute SARS-CoV-2 infection. The median age of the patient cohort was 69 (IQR 55-79) years. 12 (52.2%) patients were men. Peripheral monocytes and chemokine/cytokine profiles were analysed.
Results: Numbers of classical and non-classical monocytes were significantly decreased during acute SARS-CoV-2 infection compared to 3-month recovery. While classical monocytes reached the expected level in peripheral blood after 3 months, the number of non-classical monocytes remained significantly reduced.
Discussion: All three monocyte subsets exhibited changes of established adhesion and activation markers. Interestingly, they also expressed higher levels of pro-inflammatory cytokines like macrophage migration inhibitory factor (MIF) at the time of recovery, although MIF was only slightly increased during the acute phase.
Conclusion: Changes of monocyte phenotypes and increased MIF expression after 3-month recovery from acute SARS-CoV-2 infection may indicate persistent, possibly long-lasting, pro-inflammatory monocyte function in CVD patients.
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje