Longitudinal associations between cardiovascular biomarkers and metabolic syndrome during puberty: the PUBMEP study.

Autor: González-Gil EM; Department of Biochemistry and Molecular Biology II, Center of Biomedical Research (CIBM), Instituto de Nutrición Y Tecnología de los Alimentos, Universidad de Granada, Granada, Spain.; GENUD (Growth, Exercise, NUtrition and Development) Research Group, Universidad de Zaragoza, Zaragoza, Spain.; CIBEROBN (Physiopathology of Obesity and Nutrition Network), Institute of Health Carlos III (ISCIII), Madrid, Spain., Anguita-Ruiz A; Department of Biochemistry and Molecular Biology II, Center of Biomedical Research (CIBM), Instituto de Nutrición Y Tecnología de los Alimentos, Universidad de Granada, Granada, Spain.; Instituto de Investigación Biosanitaria IBS, Granada, Spain., Kalén A; Unit of Investigation in Nutrition, Growth and Human Development of Galicia, Pediatric Department, Clinic University Hospital of Santiago, University of Santiago de Compostela, Santiago de Compostela, Spain., De Las Lamas Perez C; Unit of Investigation in Nutrition, Growth and Human Development of Galicia, Pediatric Department, Clinic University Hospital of Santiago, University of Santiago de Compostela, Santiago de Compostela, Spain., Rupérez AI; GENUD (Growth, Exercise, NUtrition and Development) Research Group, Universidad de Zaragoza, Zaragoza, Spain., Vázquez-Cobela R; CIBEROBN (Physiopathology of Obesity and Nutrition Network), Institute of Health Carlos III (ISCIII), Madrid, Spain.; Unit of Investigation in Nutrition, Growth and Human Development of Galicia, Pediatric Department, Clinic University Hospital of Santiago, University of Santiago de Compostela, Santiago de Compostela, Spain., Flores K; Metabolism and Investigation Unit, Reina Sofia University Hospital, Maimónides Institute of Biomedicine Research of Córdoba (IMIBIC), University of Córdoba, Córdoba, Spain., Gil A; Department of Biochemistry and Molecular Biology II, Center of Biomedical Research (CIBM), Instituto de Nutrición Y Tecnología de los Alimentos, Universidad de Granada, Granada, Spain.; CIBEROBN (Physiopathology of Obesity and Nutrition Network), Institute of Health Carlos III (ISCIII), Madrid, Spain.; Instituto de Investigación Biosanitaria IBS, Granada, Spain., Gil-Campos M; CIBEROBN (Physiopathology of Obesity and Nutrition Network), Institute of Health Carlos III (ISCIII), Madrid, Spain.; Instituto de Investigación Biosanitaria IBS, Granada, Spain., Bueno G; GENUD (Growth, Exercise, NUtrition and Development) Research Group, Universidad de Zaragoza, Zaragoza, Spain.; CIBEROBN (Physiopathology of Obesity and Nutrition Network), Institute of Health Carlos III (ISCIII), Madrid, Spain.; Pediatric Endocrinology Unit, Facultad de Medicina, Clinic University Hospital Lozano Blesa, Universidad de Zaragoza, Zaragoza, 50009, Spain., Leis R; CIBEROBN (Physiopathology of Obesity and Nutrition Network), Institute of Health Carlos III (ISCIII), Madrid, Spain. mariarosaura.leis@usc.es.; Unit of Investigation in Nutrition, Growth and Human Development of Galicia, Pediatric Department, Clinic University Hospital of Santiago, University of Santiago de Compostela, Santiago de Compostela, Spain. mariarosaura.leis@usc.es., Aguilera CM; Department of Biochemistry and Molecular Biology II, Center of Biomedical Research (CIBM), Instituto de Nutrición Y Tecnología de los Alimentos, Universidad de Granada, Granada, Spain.; CIBEROBN (Physiopathology of Obesity and Nutrition Network), Institute of Health Carlos III (ISCIII), Madrid, Spain.; Instituto de Investigación Biosanitaria IBS, Granada, Spain.
Jazyk: angličtina
Zdroj: European journal of pediatrics [Eur J Pediatr] 2023 Jan; Vol. 182 (1), pp. 419-429. Date of Electronic Publication: 2022 Nov 15.
DOI: 10.1007/s00431-022-04702-6
Abstrakt: Puberty has been described as a life stage of considerable metabolic risk specially for those with obesity. The low-grade systemic inflammatory status associated with obesity could be one of the connections with metabolic syndrome (MetS). Thus, we aimed to assess the relationship between inflammatory and cardiovascular biomarkers and the development of MetS during puberty. Seventy-five children from the PUBMEP study (33 females), aged 4-18 years, were included. Cardiovascular and inflammatory biomarkers were measured in the prepubertal and pubertal stage, including high-sensitivity C-reactive protein (CRP), leptin, tumor necrosis factor-alpha (TNFα), interleukin 8 (IL8), monocyte chemoattractant protein 1 (MCP-1), total plasminogen activator inhibitor-1 (tPAI), resistin, adiponectin, myeloperoxidase (MPO), and soluble intercellular adhesion molecule-1 (sICAM-1). MetS was diagnosed at each measurement point. Mixed-effects and logistic regressions were performed. Those children with MetS in puberty presented higher prepubertal values of several cardiometabolic biomarkers in comparison to those without MetS (z-score body mass index (zBMI), waist circumference, insulin, HOMA-IR, leptin, and tPAI (p < 0.05)). For prepubertal children with obesity, the odds of developing MetS in puberty were significantly higher in those having high zBMI (OR = 4.27; CI: 1.39-22.59) or high concentrations of tPAI (OR = 1.19; CI: 1.06-1.43).
Conclusion: Those with obesity with higher prepubertal tPAI plasma levels had 19% higher odds of having MetS at puberty highlighting the existence of association between MetS, obesity, and inflammation already in puberty. Thus, assessing cardiometabolic and inflammatory status in children with obesity already at prepuberty is key to avoiding future comorbidities.
What Is Known: • Inflammation, metabolic syndrome, and obesity may have their onset in childhood. • Puberty is a life stage characterized for an increased cardiovascular risk.
What Is New: • Prepuberty state could be an early indicator of future cardiometabolic risk. • Children with obesity and high total plasminogen have higher odds of future metabolic syndrome.
(© 2022. The Author(s).)
Databáze: MEDLINE
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