In Vitro Comparison Between Ovine and Human Recombinant Hyaluronidase on Hyaluronic Acid Fillers.
| Autor: | Beatrous BP; Department of Otolaryngology-Head and Neck Surgery, University of Mississippi Medical Center, Jackson, Mississippi, USA., Liddell PH; School of Medicine, University of Mississippi Medical Center, Jackson, Mississippi, USA., Turner LM; Department of Cell & Molecular Biology, University of Mississippi Medical Center, Jackson, Mississippi, USA., Raucher D; Department of Cell & Molecular Biology, University of Mississippi Medical Center, Jackson, Mississippi, USA., Jordan JR; Department of Otolaryngology-Head and Neck Surgery, University of Mississippi Medical Center, Jackson, Mississippi, USA. |
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| Jazyk: | angličtina |
| Zdroj: | Facial plastic surgery & aesthetic medicine [Facial Plast Surg Aesthet Med] 2023 Sep-Oct; Vol. 25 (5), pp. 391-395. Date of Electronic Publication: 2022 Nov 14. |
| DOI: | 10.1089/fpsam.2022.0082 |
| Abstrakt: | Introduction: Injectable hyaluronic acid (HA) fillers are commonly used to provide tissue augmentation and combat the effects of facial aging. Ovine and human recombinant formulations of the enzyme hyaluronidase (HAse) are used interchangeably; however, it is unknown if there exists a difference in their ability to degrade HA. Objective: To compare rates at which ovine and human recombinant forms of HAse degrade various HA fillers in vitro. Methods: Increasing amounts of either ovine or human recombinant HAse were added to fixed amounts of nine unique HA filler products. Degradation rates were then analyzed using a colorimetric method by measuring absorbance levels of degraded product. Results: Human recombinant HAse degraded more HA when compared with ovine HAse overall ( p = 0.014, confidence interval [-0.015 to -0.0018]). Conclusions: Human recombinant HAse was found to be more effective on average in degrading HA fillers when compared with ovine HAse in vitro. |
| Databáze: | MEDLINE |
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