An injectable and self-healing cellulose nanofiber-reinforced alginate hydrogel for bone repair.

Autor: Cui S; Shaanxi Provincial Key Laboratory of Papermaking Technology and Specialty Paper Development, National Demonstration Center for Experimental Light Chemistry Engineering Education, Key Laboratory of Paper Based Functional Materials of China National Light Industry, Shaanxi University of Science and Technology, Xi'an 710021, China., Zhang S; Shaanxi Provincial Key Laboratory of Papermaking Technology and Specialty Paper Development, National Demonstration Center for Experimental Light Chemistry Engineering Education, Key Laboratory of Paper Based Functional Materials of China National Light Industry, Shaanxi University of Science and Technology, Xi'an 710021, China. Electronic address: zhangsufeng@sust.edu.cn., Coseri S; 'Petru Poni' Institute of Macromolecular Chemistry, Romanian Academy, 41 A Gr. Ghica Voda Alley, Iasi 700487, Romania.
Jazyk: angličtina
Zdroj: Carbohydrate polymers [Carbohydr Polym] 2023 Jan 15; Vol. 300, pp. 120243. Date of Electronic Publication: 2022 Oct 20.
DOI: 10.1016/j.carbpol.2022.120243
Abstrakt: Biomedical materials are in high demand for transplantation in cases of diseased or damaged bone tissue. Hydrogels are potential candidates for bone defect repair; however, traditional hydrogels lack the necessary strength and multiple functions. Herein, we effectively synthesized a cellulose nanofiber (CNF)-reinforced oxidized alginate (OSA)/gelatin (Gel) semi-interpenetrating network hydrogel through a facile one-step approach without a cross-linker by using the synergistic effects of dynamic imine bonds and hydrogen bonds. The OSA/Gel/CNF sample showed a notable compressive modulus (up to 361.3 KPa). The gelation time (~150 s) ensured excellent injectability. Self-healing exhibited a high efficiency of up to 92 %, which would enable minimally invasive, dynamic adjustments and personalized therapies. Furthermore, the OSA/Gel/CNF hydrogel showed excellent biomineralization (Ca/P ratio ~ 1.69) and enhanced preosteoblast cell (MC3T3-E1) viability (over 96 %), proliferation, and osteogenic differentiation. Thus, this multifunctional hydrogel has promising potential for using in the bone tissue repairs.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2022 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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