9-PAHPA long term intake in DIO and db/db mice ameliorates insulin sensitivity but has few effects on obesity and associated metabolic disorders.

Autor: Bonafos B; DMEM, INRAE, Univ Montpellier, Montpellier, France., Cortés-Espinar AJ; Nutrigenomics Research Group, Department of Biochemistry and Biotechnology, Universitat Rovira i Virgili, Tarragona, Spain., Balas L; IBMM, Univ. Montpellier, CNRS, ENSCM, Montpellier, France., Pessemesse L; DMEM, INRAE, Univ Montpellier, Montpellier, France., Lambert K; INSERM U1046, Montpellier, France., Benlebna M; DMEM, INRAE, Univ Montpellier, Montpellier, France., Gaillet S; DMEM, INRAE, Univ Montpellier, Montpellier, France., Pelletier F; DMEM, INRAE, Univ Montpellier, Montpellier, France., Delobel P; DMEM, INRAE, Univ Montpellier, Montpellier, France., Ávila-Román J; Molecular and Applied Pharmacology Group (FARMOLAP), Department of Pharmacology, Faculty of Pharmacy, Reina Mercedes Campus, Universidad de Sevilla, Sevilla, Spain., Abellán MM; Nutrigenomics Research Group, Department of Biochemistry and Biotechnology, Universitat Rovira i Virgili, Tarragona, Spain., Bertrand-Gaday C; DMEM, INRAE, Univ Montpellier, Montpellier, France., Durand T; IBMM, Univ. Montpellier, CNRS, ENSCM, Montpellier, France., Coudray C; DMEM, INRAE, Univ Montpellier, Montpellier, France., Casas F; DMEM, INRAE, Univ Montpellier, Montpellier, France. Electronic address: francois.casas@inrae.fr., Feillet-Coudray C; DMEM, INRAE, Univ Montpellier, Montpellier, France. Electronic address: christine.coudray@inrae.fr.
Jazyk: angličtina
Zdroj: The Journal of nutritional biochemistry [J Nutr Biochem] 2023 Feb; Vol. 112, pp. 109216. Date of Electronic Publication: 2022 Nov 11.
DOI: 10.1016/j.jnutbio.2022.109216
Abstrakt: Branched fatty acid esters of hydroxy fatty acids are endogenous lipids reported to have antidiabetic and anti-inflammatory effects. Recently, we showed that 9-palmitic acid esters of hydroxypalmitic acid (9-PAHPA) and 9-oleic acid esters of hydroxypalmitic acid increased insulin sensitivity in mice when incorporated to a chow diet or to a high fat and high sucrose diet. However, preventive supplementation with 9-PAHPA and 9-oleic acid esters of hydroxypalmitic acid in high fat and high sucrose diet mice did not impair significant weight gain or the development of hyperglycemia. The aim of this work was therefore to study whether in two animal models of obesity, namely the classical diet-induced obesity (DIO) and the db/db mice, 9-PAHPA may have beneficial effects against obesity and liver and skeletal muscle metabolic dysfunction. In DIO mice, we observed that 9-PAHPA increased body weight and fat mass. In line with this observation, we found that 9-PAHPA supplementation decreased energy expenditure. In liver and in skeletal muscle, mitochondrial activities and oxidative stress parameters were not modified by 9-PAHPA supplementation. In db/db mice, 9-PAHPA had no effect on the dramatic weight gain and hyperglycemia. In addition, 9-PAHPA supplementation did not correct either the hepatomegaly and hepatic steatosis or the severe muscle atrophy recorded compared with db/+ animals. Likewise, supplementation with 9-PAHPA did not impact the different metabolic parameters analyzed, either in the liver or in the skeletal muscles. However, it decreased insulin resistance in DIO and db/db mice. In conclusion, our study indicated that a long-term intake of 9-PAHPA in DIO and db/db mice improved insulin sensitivity but had only few effects on obesity and associated metabolic disorders.
(Copyright © 2022 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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