Towards a load bearing hydrogel: A proof of principle in the use of osmotic pressure for biomimetic cartilage constructs.

Autor: Schuiringa GH; Orthopaedic Biomechanics, Dept. Biomedical Engineering, Eindhoven University of Technology, the Netherlands., Pastrama M; Orthopaedic Biomechanics, Dept. Biomedical Engineering, Eindhoven University of Technology, the Netherlands., Ito K; Orthopaedic Biomechanics, Dept. Biomedical Engineering, Eindhoven University of Technology, the Netherlands., van Donkelaar CC; Orthopaedic Biomechanics, Dept. Biomedical Engineering, Eindhoven University of Technology, the Netherlands. Electronic address: c.c.v.donkelaar@tue.nl.
Jazyk: angličtina
Zdroj: Journal of the mechanical behavior of biomedical materials [J Mech Behav Biomed Mater] 2023 Jan; Vol. 137, pp. 105552. Date of Electronic Publication: 2022 Nov 08.
DOI: 10.1016/j.jmbbm.2022.105552
Abstrakt: Cartilage defects occur frequently and can lead to osteoarthritis. Hydrogels are a promising regenerative strategy for treating such defects, using their ability of mimicking the native extracellular matrix. However, commonly used hydrogels for tissue regeneration are too soft to resist load-bearing in the joint. To overcome this, an implant is being developed in which the mechanical loadbearing function originates from the osmotic pressure generated by the swelling potential of a charged hydrogel, which is restricted from swelling by a textile spacer fabric. This study aims to quantify the relationship between the swelling potential of the hydrogel and the compressive stiffness of the implant.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2022 The Authors. Published by Elsevier Ltd.. All rights reserved.)
Databáze: MEDLINE
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