Maternal prenatal cortisol trajectories predict accelerated growth in infancy.

Autor: Hahn-Holbrook J; Department of Psychology, University of California, 5200 Lake Rd, Merced, CA 95343, the United States of America. Electronic address: jhahn-holbrook@ucmerced.edu., Davis EP; Department of Psychology, University of Denver, 2155 S Race St, Denver, CO 80210, the United States of America; Department of Pediatrics, University of California, Irvine, CA 333 The City Blvd. West, Suite 800, Orange, CA 92868-4482, the United States of America. Electronic address: Elysia.Davis@du.edu., Sandman CA; Department of Psychiatry and Human Behavior, University of California, Irvine, CA UCI School of Medicine Medical Education, 1001 Health Sciences Road, Irvine, CA 92697-4089, the United States of America. Electronic address: casandma@uci.edu., Glynn LM; Department of Psychology, Chapman University, One University Drive, Orange, CA 92866, the United States of America. Electronic address: lglynn@chapman.edu.
Jazyk: angličtina
Zdroj: Psychoneuroendocrinology [Psychoneuroendocrinology] 2023 Jan; Vol. 147, pp. 105957. Date of Electronic Publication: 2022 Oct 21.
DOI: 10.1016/j.psyneuen.2022.105957
Abstrakt: Higher maternal cortisol in pregnancy has been linked to childhood obesity. Much of the previous research has been limited in that cortisol in pregnancy is only measured at one time-point, precluding the ability to examine critical timing effects of prenatal maternal cortisol. To fill this gap, this longitudinal study measured maternal plasma cortisol at 15, 19, 25, and 31 weeks of pregnancy, and assessed infant body mass index percentile (BMIP) 1 at birth, 3, 6, 12, and 24 months in 189 mother-infant pairs. Three distinct patterns of maternal cortisol in pregnancy (typical, steep, and flat trajectories) were identified using general growth mixture modeling (GGMM) 2 and then used to predict child growth patterns using multilevel modeling. Infants of mothers who had flat cortisol trajectories, characterized by relatively high cortisol in early gestation that plateaus by mid-gestation, experienced more rapid increases in BMIP from birth to 6 months, and had higher BMIPs at 3 and 6 months, than infants whose mothers had the typical slow cortisol rise over gestation, or steep (rapidly accelerating) trajectories. These results suggest that it is not just the total amount of maternal cortisol in pregnancy that shapes early infant growth, but instead the timing and trajectory of prenatal cortisol exposure. To better understand the early origins of obesity risk, future research is needed to investigate the factors that shape mothers' prenatal cortisol trajectories.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2022. Published by Elsevier Ltd.)
Databáze: MEDLINE
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