Simultaneous transcranial electrical and magnetic stimulation boost gamma oscillations in the dorsolateral prefrontal cortex.

Autor: Maiella M; Department of Behavioural and Clinical Neurology, Santa Lucia Foundation IRCCS, Via Ardeatina, 306, 00179, Rome, Italy., Casula EP; Department of Behavioural and Clinical Neurology, Santa Lucia Foundation IRCCS, Via Ardeatina, 306, 00179, Rome, Italy.; Department of Psychology, La Sapienza University, Rome, Italy., Borghi I; Department of Behavioural and Clinical Neurology, Santa Lucia Foundation IRCCS, Via Ardeatina, 306, 00179, Rome, Italy.; Center for Translational Neurophysiology of Speech and Communication, Istituto Italiano di Tecnologia (IIT), Ferrara, Italy., Assogna M; Department of Behavioural and Clinical Neurology, Santa Lucia Foundation IRCCS, Via Ardeatina, 306, 00179, Rome, Italy., D'Acunto A; Department of Behavioural and Clinical Neurology, Santa Lucia Foundation IRCCS, Via Ardeatina, 306, 00179, Rome, Italy., Pezzopane V; Department of Behavioural and Clinical Neurology, Santa Lucia Foundation IRCCS, Via Ardeatina, 306, 00179, Rome, Italy., Mencarelli L; Department of Behavioural and Clinical Neurology, Santa Lucia Foundation IRCCS, Via Ardeatina, 306, 00179, Rome, Italy., Rocchi L; Department of Medical Sciences and Public Health, Institute of Neurology, University of Cagliari, Cagliari, Italy., Pellicciari MC; Department of Behavioural and Clinical Neurology, Santa Lucia Foundation IRCCS, Via Ardeatina, 306, 00179, Rome, Italy., Koch G; Department of Behavioural and Clinical Neurology, Santa Lucia Foundation IRCCS, Via Ardeatina, 306, 00179, Rome, Italy. g.koch@hsantalucia.it.; Department of Neuroscience and Rehabilitation, University of Ferrara, Ferrara, Italy. g.koch@hsantalucia.it.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2022 Nov 12; Vol. 12 (1), pp. 19391. Date of Electronic Publication: 2022 Nov 12.
DOI: 10.1038/s41598-022-23040-z
Abstrakt: Neural oscillations in the gamma frequency band have been identified as a fundament for synaptic plasticity dynamics and their alterations are central in various psychiatric and neurological conditions. Transcranial magnetic stimulation (TMS) and alternating electrical stimulation (tACS) may have a strong therapeutic potential by promoting gamma oscillations expression and plasticity. Here we applied intermittent theta-burst stimulation (iTBS), an established TMS protocol known to induce LTP-like cortical plasticity, simultaneously with transcranial alternating current stimulation (tACS) at either theta (θtACS) or gamma (γtACS) frequency on the dorsolateral prefrontal cortex (DLPFC). We used TMS in combination with electroencephalography (EEG) to evaluate changes in cortical activity on both left/right DLPFC and over the vertex. We found that simultaneous iTBS with γtACS but not with θtACS resulted in an enhancement of spectral gamma power, a trend in shift of individual peak frequency towards faster oscillations and an increase of local connectivity in the gamma band. Furthermore, the response to the neuromodulatory protocol, in terms of gamma oscillations and connectivity, were directly correlated with the initial level of cortical excitability. These results were specific to the DLPFC and confined locally to the site of stimulation, not being detectable in the contralateral DLPFC. We argue that the results described here could promote a new and effective method able to induce long-lasting changes in brain plasticity useful to be clinically applied to several psychiatric and neurological conditions.
(© 2022. The Author(s).)
Databáze: MEDLINE
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