B cells in human lymphoid structures.
| Autor: | Montorsi L; Peter Gorer Department of Immunobiology, School of Immunology and Microbial Sciences, King's College London, London, UK., Siu JHY; Peter Gorer Department of Immunobiology, School of Immunology and Microbial Sciences, King's College London, London, UK., Spencer J; Peter Gorer Department of Immunobiology, School of Immunology and Microbial Sciences, King's College London, London, UK. |
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| Jazyk: | angličtina |
| Zdroj: | Clinical and experimental immunology [Clin Exp Immunol] 2022 Dec 31; Vol. 210 (3), pp. 240-252. |
| DOI: | 10.1093/cei/uxac101 |
| Abstrakt: | Most B cells in the human body are present in tissues where they support immune responses to pathogens, vaccines, autoantigens, and tumours. Despite their clear importance, they are very difficult to study and there are many areas of uncertainty that are difficult to resolve because of limited tissue access. In this review, we consider the zonal structure of lymphoid tissues, the B cell subsets they contain, and how these are regulated. We also discuss the impact that methods of deep interrogation have made on our current knowledge base, especially with respect to studies of cells from dissociated tissues. We discuss in some detail the controversial B cells with marginal zone distribution that some consider being archived memory B cells. We anticipate that more we understand of B cells in tissues and the niches they create, the more opportunities will be identified to harness their potential for therapeutic benefit. (© The Author(s) 2022. Published by Oxford University Press on behalf of the British Society for Immunology.) |
| Databáze: | MEDLINE |
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