| Autor: |
Sobajo OA; Department of Biological Sciences, Faculty of Natural Sciences, Redeemer's University, Ede, Nigeria.; African Centre of Excellence for Genomics of Infectious Diseases, Redeemer's University, Ede, Nigeria.; Department of Biological Sciences, Afe Babalola University, Ado-Ekiti, Nigeria., George UE; Department of Biological Sciences, Faculty of Natural Sciences, Redeemer's University, Ede, Nigeria.; African Centre of Excellence for Genomics of Infectious Diseases, Redeemer's University, Ede, Nigeria., Osasona OG; Department of Biological Sciences, Faculty of Natural Sciences, Redeemer's University, Ede, Nigeria.; African Centre of Excellence for Genomics of Infectious Diseases, Redeemer's University, Ede, Nigeria., Eromon P; African Centre of Excellence for Genomics of Infectious Diseases, Redeemer's University, Ede, Nigeria., Aborisade OY; Haematology and Blood Transfusion Service Department, UNIOSUN Teaching Hospital, Osogbo, Nigeria., Ajayi OD; Department of Medical Laboratory Science, Afe Babalola University, Ado-Ekiti, Nigeria., Folarin OA; Department of Biological Sciences, Faculty of Natural Sciences, Redeemer's University, Ede, Nigeria.; African Centre of Excellence for Genomics of Infectious Diseases, Redeemer's University, Ede, Nigeria., Komolafe IOO; Department of Biological Sciences, Faculty of Natural Sciences, Redeemer's University, Ede, Nigeria. |
| Abstrakt: |
Infection with both Hepatitis B (HBV) and D (HDV) virus causes more severe liver damage than HBV alone. Superinfections among chronic HBV infected cohorts often lead to HDV persistence with rapid progression to cirrhosis, necessitating continuous surveillance to determine their prevalence and relative contribution to liver pathology. A cross-sectional study among hospital outpatients in Ekiti and Osunstates was conducted using random sampling technique. Blood samples were collected from 410 participants and tested for HBV serological markers. All samples positive for HBsAg samples were tested for Hepatitis D virus antigen (HDAg), serum anti-HDV IgM, and serum anti-HDV IgG using enzyme-linked immunosorbent assay kits. The prevalence of HBV infection among the 410 samples was 12.4% (CI 9.5-15.9). Past HBV exposure was detected in 120 (29.2%), while 147(35.8%) were susceptible to HBV infection. Among the HBsAg positive individuals, 9.8% were hepatitis D antigen (HDAg) positive, while 3.9% and 1.9% were positive for IgG anti-HDV and IgM anti-HDV, respectively. Risk factors associated with HBV infections in this study were multiple sexual partners and sharing of sharp objects. Our investigation has verified the endemicity of HBV in Nigeria and revealed that HBV- HDV co-infection is highly prevalent in south-west Nigeria. |
