The IPTA Nashville consensus conference on Post-Transplant lymphoproliferative disorders after solid organ transplantation in children: II-consensus guidelines for prevention.

Autor: Green M; Division of Pediatric Infectious Diseases, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA., Squires JE; Division of Gastroenterology, Hepatology and Nutrition, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA., Chinnock RE; Loma Linda University Children's Hospital, California, USA., Comoli P; Cell Factory & Pediatric Hematology/Oncology, Fondazione IRCCS Policlinico, San Matteo, Pavia, Italy., Danziger-Isakov L; Division of Infectious Disease, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio, USA., Dulek DE; Division of Pediatric Infectious Diseases, Monroe Carell Jr. Children's Hospital at Vanderbilt and Vanderbilt University Medical Center, Nashville, Tennessee, USA., Esquivel CO; Stanford University School of Medicine, Stanford, California, USA., Höcker B; Pediatrics I, University Children's Hospital, Heidelberg, Germany., L'Huillier AG; Pediatric Infectious Diseases Unit and Laboratory of Virology, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland., Mazariegos GV; Hillman Center for Pediatric Transplantation, UPMC Children's Hospital of Pittsburgh and Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA., Visner GA; Division of Pulmonary Medicine, Boston Children's Hospital/Harvard Medical School, Boston, Massachusetts, USA., Bollard CM; Center for Cancer and Immunology Research, Children's National Hospital, The George Washington University, Washington, District of Columbia, USA., Dipchand AI; Labatt Family Heart Centre, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada., Ferry JA; Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts, USA., Gross TG; Center for Cancer and Blood Diseases, Children's Hospital Colorado, Aurora, Colorado, USA., Hayashi R; Division of Pediatric Hematology/Oncology, Washington University School of Medicine, St. Louis Children's Hospital, St. Louis, Missouri, USA., Maecker-Kolhoff B; Hannover Medical School, Pediatric Hematology and Oncology, Hannover, Germany., Marks S; Department of Paediatric Nephrology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.; NIHR Great Ormond Street Hospital Biomedical Research Centre, University College London, Great Ormond Street Institute of Child Health, London, UK., Martinez OM; Department of Surgery and Program in Immunology, Stanford University School of Medicine, Stanford, California, USA., Metes DM; Thomas E. Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Michaels MG; Division of Pediatric Infectious Diseases, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA., Preiksaitis J; Division of Infectious Diseases, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada., Smets F; Pediatric Gastroenterology and Hepatology, Cliniques Universitaires Saint-Luc, UCLouvain, Brussels, Belgium., Swerdlow SH; Division of Hematopathology, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA., Trappe RU; Department of Hematology and Oncology, DIAKO Ev. Diakonie-Krankenhaus Bremen, Bremen, Germany and Department of Internal Medicine II: Hematology and Oncology, University Medical Centre Schleswig-Holstein, Campus Kiel, Kiel, Germany., Wilkinson JD; Department of Pediatrics, Vanderbilt School of Medicine, Nashville, Tennessee, USA., Allen U; Division of Infectious Diseases and the Transplant and Regenerative Medicine Center, Department of Paediatrics, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada., Webber SA; Department of Pediatrics, Vanderbilt School of Medicine, Nashville, Tennessee, USA., Dharnidharka VR; Department of Pediatrics, Division of Pediatric Nephrology, Hypertension & Pheresis, Washington University School of Medicine & St. Louis Children's Hospital, St. Louis, Missouri, USA.
Jazyk: angličtina
Zdroj: Pediatric transplantation [Pediatr Transplant] 2024 Feb; Vol. 28 (1), pp. e14350. Date of Electronic Publication: 2022 Nov 11.
DOI: 10.1111/petr.14350
Abstrakt: The International Pediatric Transplant Association (IPTA) convened an expert consensus conference to assess current evidence and develop recommendations for various aspects of care relating to post-transplant lymphoproliferative disorder after solid organ transplantation in children. In this report from the Prevention Working Group, we reviewed the existing literature regarding immunoprophylaxis and chemoprophylaxis, and pre-emptive strategies. While the group made a strong recommendation for pre-emptive reduction of immunosuppression at the time of EBV DNAemia (low to moderate evidence), no recommendations for use could be made for any prophylactic strategy or alternate pre-emptive strategy, largely due to insufficient or conflicting evidence. Current gaps and future research priorities are highlighted.
(© 2022 Wiley Periodicals LLC.)
Databáze: MEDLINE
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