Effect of an intervention of exercise on sleep and seizure frequency in idiopathic epileptic dogs.

Autor: Grady K; Department of Medical Sciences, University of Wisconsin - Madison, School of Veterinary Medicine, 2015 Linden Drive, Madison, Wisconsin, 53706, USA., Cameron S; Department of Medical Sciences, University of Wisconsin - Madison, School of Veterinary Medicine, 2015 Linden Drive, Madison, Wisconsin, 53706, USA., Kent SP; Department of Medical Sciences, University of Wisconsin - Madison, School of Veterinary Medicine, 2015 Linden Drive, Madison, Wisconsin, 53706, USA., Barnes Heller H; Barnes Veterinary Specialty Service, Madison, Wisconsin, 53716, USA., Barry MM; Department of Medical Sciences, University of Wisconsin - Madison, School of Veterinary Medicine, 2015 Linden Drive, Madison, Wisconsin, 53706, USA.
Jazyk: angličtina
Zdroj: The Journal of small animal practice [J Small Anim Pract] 2023 Feb; Vol. 64 (2), pp. 59-68. Date of Electronic Publication: 2022 Nov 11.
DOI: 10.1111/jsap.13568
Abstrakt: Objective: The goal of this study was to compare sleep and seizure frequency between epileptic dogs prescribed a 20% activity increase and epileptic dogs not prescribed an activity increase.
Methods: Sixty-nine dogs receiving anti-epileptic drug therapy were enrolled in a 6-month prospective, randomised, placebo-controlled clinical trial with an intention-to-treat analysis. A canine activity monitoring device was used to measure activity levels and sleep scores.
Results: Using an intention-to-treat analysis, the treatment group had an average of 0.381 more seizures per month (95% CI: 0.09 to 0.68) compared with the control group, although the difference in seizure days per month was not statistically significant. In a subgroup analysis of dogs whose activity increased by at least 10%, partial compliers had 0.719 more seizures per month (95% CI: 0.22 to 1.22) and 0.581 seizure days per month (95% CI: 0.001 to 1.16) compared with the control group. Sleep scores increased by 1.2% in the treatment compared with the control group (95% CI: 0.2 to 2.3%).
Conclusions: Seizure frequency and sleep score increased slightly, but significantly, in dogs with idiopathic epilepsy prescribed an increase in activity, compared with a control group.
(© 2022 The Authors. Journal of Small Animal Practice published by John Wiley & Sons Ltd on behalf of British Small Animal Veterinary Association.)
Databáze: MEDLINE
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