Societal Preferences for Meningococcal B Vaccination in Children: A Discrete Choice Experiment in Spain.

Autor: Martinón-Torres F; Translational Pediatrics and Infectious Diseases, Pediatrics Department, Hospital Clínico Universitario de Santiago de Compostela, Santiago de Compostela, Spain.; Genetics, Vaccines and Infections Research Group (GENVIP), Instituto de Investigación Sanitaria de Santiago, University of Santiago de Compostela, Santiago de Compostela, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Madrid, Spain., de Miguel ÁG; Department of Preventive Medicine and Public Health, Universidad Rey Juan Carlos, Madrid, Spain., Ruiz-Contreras J; Department of Pediatrics, Hospital Universitario 12 de Octubre, Madrid, Spain.; Department of Pediatrics, Faculty of Medicine, Universidad Complutense de Madrid, Madrid, Spain., Vallejo-Aparicio LA; GSK, Madrid, Spain. laura.a.vallejo@gsk.com., García A; GSK, Madrid, Spain., Gonzalez-Inchausti MC; GSK, Madrid, Spain., de Gomensoro E; GSK, Madrid, Spain., Kocaata Z; GSK, Wavre, Belgium., Gabás-Rivera C; Outcomes'10, Castellón, Spain., Comellas M; Outcomes'10, Castellón, Spain., Prades M; Outcomes'10, Castellón, Spain., Lizán L; Outcomes'10, Castellón, Spain.; Department of Medicine, Universidad Jaime I, Castellón, Spain.
Jazyk: angličtina
Zdroj: Infectious diseases and therapy [Infect Dis Ther] 2023 Jan; Vol. 12 (1), pp. 157-175. Date of Electronic Publication: 2022 Nov 11.
DOI: 10.1007/s40121-022-00708-7
Abstrakt: Introduction: Immunization is the most effective strategy for the prevention of invasive meningococcal disease caused by Neisseria meningitidis serogroup B (MenB); however, parents need to weigh the risk-benefit and financial impact of immunizing their children against MenB in the absence of a national immunization program (NIP). This study aimed to explore societal preferences (of parents and pediatricians) regarding the attributes of a MenB vaccine in Spain.
Methods: A discrete choice experiment (DCE) based on cross-sectional surveys was carried out to determine preferences. A literature review and scientific committee determined the six attributes related to the MenB vaccine included in the DCE: vaccination age, cost, duration, percentage of protection, adverse events probability, and expert/authority recommendation. Data were analyzed using a mixed logit model. Relative importance (RI) of attributes was calculated and compared between parents and pediatricians.
Results: A total of 278 parents [55.8% female, mean age 40.4 (standard deviation, SD 7.3) years] and 200 pediatricians [73.0% female, mean age 45.8 (SD 12.9) years] answered the DCE. For parents, the highest RI was attributed to vaccine cost, expert/authority recommendation, and percentage of protection (26.4%, 26.1%, and 22.9%, respectively), while for pediatricians the highest RI was assigned to percentage of protection, expert/authority recommendation, and vaccination age (27.2%, 23.7%, and 22.6%, respectively). Significant differences between parents and pediatricians were found in the RI assigned to all attributes (p < 0.001), except for vaccine recommendation.
Conclusion: In the decision regarding MenB vaccination, cost was a driver in parental decision-making but had a low RI for pediatricians and, conversely, vaccination age was highly valued by pediatricians but was the attribute with least importance for parents. Despite these differences, expert/authority recommendation and percentage of protection were essential criteria for both groups. These results provide relevant information about MenB vaccination, highlighting the importance of considering societal preferences for NIP inclusion.
(© 2022. GSK.)
Databáze: MEDLINE
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