Melanocortin Receptors: Emerging Targets for the Treatment of Pigmentation, Inflammation, Stress, Weight Disorders and Sexual Dysfunction.
| Autor: | Maurya MR; Department of Clinical Pharmacology, Topiwala National Medical College and BYL Nair Charitable Hospital, AL Nair road, Mumbai-400008, Mumbai, Maharashtra, India., Munshi R; Department of Clinical Pharmacology, Topiwala National Medical College and BYL Nair Charitable Hospital, AL Nair road, Mumbai-400008, Mumbai, Maharashtra, India., Zambare S; Department of Nephrology, Sterling Hospital, Vadodara, Gujarat, India. |
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| Jazyk: | angličtina |
| Zdroj: | Current drug targets [Curr Drug Targets] 2023; Vol. 24 (2), pp. 151-156. |
| DOI: | 10.2174/1389450124666221108143006 |
| Abstrakt: | Melanocortins are tiny protein molecules formed by the post-translational cleavage of proopiomelanocortin. These are bioactive peptides that are responsible for human and lower animal pigmentation patterns, energy homeostasis, and sexual function modulation. These peptides regulate numerous physiological functions by being generated in the central nervous system and peripheral tissues. Melanocortins elicit their varied biological effects by binding to a separate family of G protein, two primary proteolytic enzymes, proconvertases 1 and 2, according to recent research. These breakthroughs have opened up new avenues for research into the role of melanocortins, antagonists, and receptors in a number of physiological activities. (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.) |
| Databáze: | MEDLINE |
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