Loss to Follow-Up from HIV Pre-Exposure Prophylaxis Care in Men Who Have Sex with Men in West Africa.

Autor: Eubanks A; Aix Marseille Univ, INSERM, IRD, SESSTIM, Sciences Economiques & Sociales de la Santé & Traitement de l'Information Médicale, ISSPAM, 13005 Marseille, France., Coulibaly B; ARCAD Santé PLUS, Bamako BP E2561, Mali., Keita BD; ARCAD Santé PLUS, Bamako BP E2561, Mali., Anoma C; Espace Confiance, Abidjan 05 BP 1456, Côte d'Ivoire., Dah TTE; Association African Solidarité, Ouagadougou 01 BP 2831, Burkina Faso.; UFR Sciences de la Santé, Université de Ouahigouya, Ouahigouya 01 BP 346, Burkina Faso., Mensah E; Espoir Vie Togo, Lomé 7 BP 14543, Togo., Maradan G; Aix Marseille Univ, INSERM, IRD, SESSTIM, Sciences Economiques & Sociales de la Santé & Traitement de l'Information Médicale, ISSPAM, 13005 Marseille, France.; ORS PACA, Observatoire Régional de la Santé Provence-Alpes-Côte d'Azur, 13005 Marseille, France., Bourrelly M; Aix Marseille Univ, INSERM, IRD, SESSTIM, Sciences Economiques & Sociales de la Santé & Traitement de l'Information Médicale, ISSPAM, 13005 Marseille, France.; Coalition Plus, Community-Based Research Laboratory, 93500 Pantin, France., Mora M; Aix Marseille Univ, INSERM, IRD, SESSTIM, Sciences Economiques & Sociales de la Santé & Traitement de l'Information Médicale, ISSPAM, 13005 Marseille, France., Riegel L; Coalition Plus, Community-Based Research Laboratory, 93500 Pantin, France., Rojas Castro D; Aix Marseille Univ, INSERM, IRD, SESSTIM, Sciences Economiques & Sociales de la Santé & Traitement de l'Information Médicale, ISSPAM, 13005 Marseille, France.; Coalition Plus, Community-Based Research Laboratory, 93500 Pantin, France., Yaya I; TransVIHMI, Univ Montpellier, INSERM, IRD, 34394 Montpellier, France., Spire B; Aix Marseille Univ, INSERM, IRD, SESSTIM, Sciences Economiques & Sociales de la Santé & Traitement de l'Information Médicale, ISSPAM, 13005 Marseille, France., Laurent C; TransVIHMI, Univ Montpellier, INSERM, IRD, 34394 Montpellier, France., Sagaon-Teyssier L; Aix Marseille Univ, INSERM, IRD, SESSTIM, Sciences Economiques & Sociales de la Santé & Traitement de l'Information Médicale, ISSPAM, 13005 Marseille, France.; ARCAD Santé PLUS, Bamako BP E2561, Mali., The CohMSM-PrEP Study Group
Jazyk: angličtina
Zdroj: Viruses [Viruses] 2022 Oct 28; Vol. 14 (11). Date of Electronic Publication: 2022 Oct 28.
DOI: 10.3390/v14112380
Abstrakt: Loss to follow-up (LTFU) from HIV pre-exposure prophylaxis (PrEP) care compromises the goal of HIV elimination. We investigated the proportion of LTFU and associated risk factors among men who have sex with men (MSM) enrolled in a PrEP demonstration project in Burkina Faso, Côte d'Ivoire, Mali, and Togo. CohMSM-PrEP, a prospective cohort study, was conducted between November 2017 and June 2021 in community-based clinics. MSM aged 18 years or older at substantial risk of HIV infection received a comprehensive prevention package, including PrEP and peer education. LTFU was defined as not returning to the clinic for six months. Associated risk factors were investigated using a time-varying Cox's model. Of 647 participants followed up for a median time of 15 months, 372 were LTFU (57.5%). LTFU was associated with younger age (adjusted hazard ratio [95% Confidence Interval]; 1.50 [1.17-1.94]), unemployment (1.33 [1.03-1.71]), depression (1.63 [1.12-2.38]), and perceiving no HIV risk with stable male partners (1.61 [1.23-2.10]). Contacting peer educators outside of scheduled visits was protective (0.74 [0.56-0.97]). Our findings show that LTFU from PrEP care in West African MSM is a major challenge to achieving HIV elimination, but that the involvement of peer educators in PrEP delivery helps to limit LTFU by providing users with adequate support.
Databáze: MEDLINE
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