Sustained Virologic Suppression Reduces HIV-1 DNA Proviral Levels and HIV Antibodies in Perinatally HIV-Infected Children Followed from Birth.

Autor: Fuller T; Institute of the Environment & Sustainability, University of California Los Angeles, Los Angeles, CA 90095, USA.; Infectious Diseases Department, Hospital Federal dos Servidores do Estado, Rio de Janeiro 20221-161, RJ, Brazil., Kerin T; Pediatric Infectious Diseases, David Geffen UCLA School of Medicine, Los Angeles, CA 90095, USA., Cortado R; Pediatric Infectious Diseases, David Geffen UCLA School of Medicine, Los Angeles, CA 90095, USA., Benamor Teixeira ML; Infectious Diseases Department, Hospital Federal dos Servidores do Estado, Rio de Janeiro 20221-161, RJ, Brazil.; Instituto Nacional de Infectologia Evandro Chagas (INI), Fundação Oswaldo Cruz (FIOCRUZ), Rio de Janeiro 21040-360, RJ, Brazil., Fragoso da Silveira Gouvêa MI; Infectious Diseases Department, Hospital Federal dos Servidores do Estado, Rio de Janeiro 20221-161, RJ, Brazil.; Instituto Nacional de Infectologia Evandro Chagas (INI), Fundação Oswaldo Cruz (FIOCRUZ), Rio de Janeiro 21040-360, RJ, Brazil., Moreira C; Infectious Diseases Department, Hospital Federal dos Servidores do Estado, Rio de Janeiro 20221-161, RJ, Brazil., Santos Cruz ML; Infectious Diseases Department, Hospital Federal dos Servidores do Estado, Rio de Janeiro 20221-161, RJ, Brazil., Pilotto JH; Hospital Geral de Nova Iguaçu, Nova Iguaçu 26030-380, RJ, Brazil.; Laboratório de AIDS e Imunologia Molecular, Instituto Oswaldo Cruz (IOC), Fundação Oswaldo Cruz, (FIOCRUZ), Rio de Janeiro 21040-360, RJ, Brazil., Gomes I; Hospital Geral de Nova Iguaçu, Nova Iguaçu 26030-380, RJ, Brazil., Santos B; Hospital Nossa Senhora da Conceição, Porto Alegre 91350-250, RS, Brazil., Rocha T; Hospital Nossa Senhora da Conceição, Porto Alegre 91350-250, RS, Brazil., Soni PR; Cedars Sinai Medical Center, Los Angeles, CA 90048, USA., Joao E; Infectious Diseases Department, Hospital Federal dos Servidores do Estado, Rio de Janeiro 20221-161, RJ, Brazil., Shin-Sim M; Pediatric Infectious Diseases, David Geffen UCLA School of Medicine, Los Angeles, CA 90095, USA., Bryson Y; Pediatric Infectious Diseases, David Geffen UCLA School of Medicine, Los Angeles, CA 90095, USA., Nielsen-Saines K; Pediatric Infectious Diseases, David Geffen UCLA School of Medicine, Los Angeles, CA 90095, USA.
Jazyk: angličtina
Zdroj: Viruses [Viruses] 2022 Oct 26; Vol. 14 (11). Date of Electronic Publication: 2022 Oct 26.
DOI: 10.3390/v14112350
Abstrakt: The extent to which perinatally HIV-infected children, following cART initiation, develop a low proviral reservoir burden over time, as measured by HIV DNA droplet-digital polymerase chain reaction (ddPCR) and the effect on HIV antibody is not well characterized. We measured proviral HIV DNA and plasma RNA virus load (VL) in 37 perinatally HIV-infected children at 6 months of age who initiated stable cART. At 6-11 years of age, HIV proviral DNA, HIV VL (RNA), and HIV antibody by Western Blot (WB) were assessed. CART was initiated before 6 months of age in 13 children and after 6 months in 24. At school age, the HIV DNA levels did not differ by the timing of cART, and the HIV DNA levels were lower in children with negative/indeterminate WB ( p = 0.0256). Children with undetectable HIV RNA VL > 50% of the time since cART initiation had lower median DNA VL than children with undetectable VL < 50% of the time ( p = 0.07). Long-term viral suppression in perinatally HIV-infected children is associated with a decrease in HIV antibodies and reduced HIV reservoirs.
Databáze: MEDLINE
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