Mechanisms of Actions Involved in The Antinociceptive Effect of Estragole and its β -Cyclodextrin Inclusion Complex in Animal Models.

Autor: da Costa RHS; Laboratory of Pharmacology and Molecular Chemistry (LFQM), Department of Biological Chemistry, Regional University of Cariri-URCA, Pimenta 63.100-000, Ceará, Brazil., Martins AOBPB; Laboratory of Pharmacology and Molecular Chemistry (LFQM), Department of Biological Chemistry, Regional University of Cariri-URCA, Pimenta 63.100-000, Ceará, Brazil., Pessoa RT; Laboratory of Pharmacology and Molecular Chemistry (LFQM), Department of Biological Chemistry, Regional University of Cariri-URCA, Pimenta 63.100-000, Ceará, Brazil., Alshehri SA; Department of Pharmacognosy, College of Pharmacy, King Khalid University, Abha 61421, Saudi Arabia., Wahab S; Department of Pharmacognosy, College of Pharmacy, King Khalid University, Abha 61421, Saudi Arabia., Ahmad MF; Department of Clinical Nutrition, College of Applied Medical Sciences, Jazan University, Jazan 45142, Saudi Arabia., Suliman M; Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Khalid University, Abha 61421, Saudi Arabia., da Silva LYS; Laboratory of Pharmacology and Molecular Chemistry (LFQM), Department of Biological Chemistry, Regional University of Cariri-URCA, Pimenta 63.100-000, Ceará, Brazil., Alcântara IS; Laboratory of Pharmacology and Molecular Chemistry (LFQM), Department of Biological Chemistry, Regional University of Cariri-URCA, Pimenta 63.100-000, Ceará, Brazil., Ramos AGB; Laboratory of Pharmacology and Molecular Chemistry (LFQM), Department of Biological Chemistry, Regional University of Cariri-URCA, Pimenta 63.100-000, Ceará, Brazil., Oliveira MRC; Laboratory of Pharmacology and Molecular Chemistry (LFQM), Department of Biological Chemistry, Regional University of Cariri-URCA, Pimenta 63.100-000, Ceará, Brazil.; Graduate Program in Biotechnology-Northeast Biotechnology Network (RENORBIO), State University of Ceará (UECE), Fortaleza 60741-000, Ceará, Brazil., Batista FLA; Laboratory of Pharmacology and Molecular Chemistry (LFQM), Department of Biological Chemistry, Regional University of Cariri-URCA, Pimenta 63.100-000, Ceará, Brazil., Delmondes GA; Nursing Academic Collegiate, Federal University of Vale do São Francisco (UNIVASF), Petrolina 56330-400, Pernambuco, Brazil., de Farias PAM; CECAPE College, Juazeiro do Norte-CE 63.024-015, Ceará, Brazil., Rocha JE; Laboratory of Microbiology and Molecular Biology, Department of Biological Chemistry, Regional University of Cariri-URCA, Pimenta 63.100-000, Ceará, Brazil., Coutinho HDM; Laboratory of Microbiology and Molecular Biology, Department of Biological Chemistry, Regional University of Cariri-URCA, Pimenta 63.100-000, Ceará, Brazil., Raposo A; CBIOS (Research Center for Biosciences and Health Technologies), Universidade Lusófona de Humanidades e Tecnologias, Campo Grande 376, 1749-024 Lisboa, Portugal., Carrascosa C; Department of Animal Pathology and Production, Bromatology and Food Technology, Faculty of Veterinary, Universidad de Las Palmas de Gran Canaria, Trasmontaña s/n, 35413 Arucas, Spain., Jaber JR; Departamento de Morfologia, Facultad de Veterinaria, Universidad de Las Palmas de Gran Canaria, 35413 Las Palmas de Gran Canaria, Spain., de Menezes IRA; Laboratory of Microbiology and Molecular Biology, Department of Biological Chemistry, Regional University of Cariri-URCA, Pimenta 63.100-000, Ceará, Brazil.
Jazyk: angličtina
Zdroj: Plants (Basel, Switzerland) [Plants (Basel)] 2022 Oct 26; Vol. 11 (21). Date of Electronic Publication: 2022 Oct 26.
DOI: 10.3390/plants11212854
Abstrakt: (1) Background: estragole is a monoterpene found in the essential oils of several aromatic plants, which can be used for several pharmacological activities. The aim of this study was to evaluate the antinociceptive effect of estragole (Es) and its β -cyclodextrins inclusion complex (Es/β-CD). (2) Methods: the effects of Es and Es/β-CD on the central nervous system (CNS) were evaluated through open field and rota-rod assays, and the antinociceptive effect in formalin models, abdominal writhing induced by acetic acid, hot plate, tail flick test and plantar mechanical hyperalgesia. (3) Results: Es and Es/β-CD showed no alterations on the CNS evaluated parameters and the results suggested there was an antinociceptive action in the formalin, abdominal writhing, hot plate, tail flick tests and plantar mechanical hyperalgesia, proposing the involvement of the nitric oxide, glutamatergic signaling pathways, cyclic guanosine monophosphate and vanilloid pathways. (4) Conclusion: the results suggest that Es and Es/β-CD have a promising antinociceptive potential as a possible alternative for the pharmacological treatment of pain, also showing that the encapsulation of Es in β-cyclodextrins probably improves its pharmacological properties, since the complexation process involves much lower amounts of the compound, contributing to better bioavailability and a lower probability of adverse effect development.
Databáze: MEDLINE