Electrospun Poly(acrylic acid- co -4-styrene sulfonate) as Potential Drug-Eluting Scaffolds for Targeted Chemotherapeutic Delivery Systems on Gastric (AGS) and Breast (MDA-Mb-231) Cancer Cell Lines.

Autor:	Neira-Carrillo A; Department of Biological and Animal Sciences, Faculty of Veterinary and Animal Sciences, University of Chile, Santa Rosa 11735, La Pintana, Santiago 8820808, Chile.; Advanced Center for Chronic Diseases (ACCDIS), Santiago 380492, Chile., Zárate IA; Department of Biological and Animal Sciences, Faculty of Veterinary and Animal Sciences, University of Chile, Santa Rosa 11735, La Pintana, Santiago 8820808, Chile., Nieto E; Department of Biological and Animal Sciences, Faculty of Veterinary and Animal Sciences, University of Chile, Santa Rosa 11735, La Pintana, Santiago 8820808, Chile., Butto-Miranda N; Department of Biological and Animal Sciences, Faculty of Veterinary and Animal Sciences, University of Chile, Santa Rosa 11735, La Pintana, Santiago 8820808, Chile., Lobos-González L; Advanced Center for Chronic Diseases (ACCDIS), Santiago 380492, Chile.; Center for Regenerative Medicine, Faculty of Medicine, Universidad del Desarrollo, Clínica Alemana, Santiago 7610658, Chile., Del Campo-Smith M; Advanced Center for Chronic Diseases (ACCDIS), Santiago 380492, Chile.; Center for Regenerative Medicine, Faculty of Medicine, Universidad del Desarrollo, Clínica Alemana, Santiago 7610658, Chile., Palacio DA; Department of Polymer Chemistry, Faculty of Chemical Science, University of Concepción, Concepción 3349001, Chile., Urbano BF; Department of Polymer Chemistry, Faculty of Chemical Science, University of Concepción, Concepción 3349001, Chile.
Jazyk:	angličtina
Zdroj:	Nanomaterials (Basel, Switzerland) [Nanomaterials (Basel)] 2022 Nov 04; Vol. 12 (21). Date of Electronic Publication: 2022 Nov 04.
DOI:	10.3390/nano12213903
Abstrakt:	Potential drug-eluting scaffolds of electrospun poly(acrylic acid- co -styrene sulfonate) P(AA- co -SS) in clonogenic assays using tumorigenic gastric and ovarian cancer cells were tested in vitro. Electrospun polymer nanofiber (EPnF) meshes of PAA and PSSNa homo- and P(AA- co -SS) copolymer composed of 30:70, 50:50, 70:30 acrylic acid (AA) and sodium 4-styrene sulfonate (SSNa) units were performed by electrospinning (ES). The synthesis, structural and morphological characterization of all EPnF meshes were analyzed by optical and electron microscopy (SEM-EDS), infrared spectroscopy (FTIR), contact angle, and X-ray diffraction (XRD) measurements. This study shows that different ratio of AA and SSNa of monomers in P(AA- co -SS) EPnF play a crucial role in clonogenic in vitro assays. We found that 50:50 P(AA- co -SS) EPnF mesh loaded with antineoplastic drugs can be an excellent suppressor of growth-independent anchored capacities in vitro assays and a good subcutaneous drug delivery system for chemotherapeutic medication in vivo model for surgical resection procedures in cancer research.
Databáze:	MEDLINE
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