Gut Microbiome and Its Cofactors Are Linked to Lipoprotein Distribution Profiles.

Autor:	Castro-Mejía JL; Department of Food Science, University of Copenhagen, 1958 Frederiksberg C, Denmark., Khakimov B; Department of Food Science, University of Copenhagen, 1958 Frederiksberg C, Denmark., Aru V; Department of Food Science, University of Copenhagen, 1958 Frederiksberg C, Denmark., Lind MV; Department of Nutrition, Exercise and Sports, University of Copenhagen, 1958 Frederiksberg C, Denmark., Garne E; Department of Food Science, University of Copenhagen, 1958 Frederiksberg C, Denmark.; Department of Biomedical Sciences, University of Copenhagen, 2200 Copenhagen N, Denmark., Paulová P; Department of Food Science, University of Copenhagen, 1958 Frederiksberg C, Denmark.; Biomedical Research Center, Institute of Experimental Endocrinology, University Science Park for Biomedicine, Dúbravská cesta 9, 94505 Bratislava, Slovakia., Tavakkoli E; Swammerdam Institute for Life Sciences, University of Amsterdam, Postbus 94215, 1090 GE Amsterdam, The Netherlands., Hansen LH; Department of Plant and Environmental Sciences, University of Copenhagen, 1871 Frederiksberg C, Denmark., Smilde AK; Department of Food Science, University of Copenhagen, 1958 Frederiksberg C, Denmark.; Swammerdam Institute for Life Sciences, University of Amsterdam, Postbus 94215, 1090 GE Amsterdam, The Netherlands., Holm L; Department of Biomedical Sciences, University of Copenhagen, 2200 Copenhagen N, Denmark.; School of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Birmingham B15 2TT, UK., Engelsen SB; Department of Food Science, University of Copenhagen, 1958 Frederiksberg C, Denmark., Nielsen DS; Department of Food Science, University of Copenhagen, 1958 Frederiksberg C, Denmark.
Jazyk:	angličtina
Zdroj:	Microorganisms [Microorganisms] 2022 Oct 31; Vol. 10 (11). Date of Electronic Publication: 2022 Oct 31.
DOI:	10.3390/microorganisms10112156
Abstrakt:	Increasing evidence indicates that the gut microbiome (GM) plays an important role in dyslipidemia. To date, however, no in-depth characterization of the associations between GM with lipoproteins distributions (LPD) among adult individuals with diverse BMI has been conducted. To determine such associations, we studied blood-plasma LPD, fecal short-chain fatty acids (SCFA) and GM of 262 Danes aged 19-89 years. Stratification of LPD segregated subjects into three clusters displaying recommended levels of lipoproteins and explained by age and body-mass-index. Higher levels of HDL2a and HDL2b were associated with a higher abundance of Ruminococcaceae and Christensenellaceae . Increasing levels of total cholesterol and LDL-1 and LDL-2 were positively associated with Lachnospiraceae and Coriobacteriaceae , and negatively with Bacteroidaceae and Bifidobacteriaceae . Metagenome-sequencing showed a higher abundance of biosynthesis of multiple B-vitamins and SCFA metabolism genes among healthier LPD profiles. Metagenomic-assembled genomes (MAGs) affiliated to Eggerthellaceae and Clostridiales were contributors of these genes and their relative abundance correlated positively with larger HDL subfractions. The study demonstrates that differences in composition and metabolic traits of the GM are associated with variations in LPD among the recruited subjects. These findings provide evidence for GM considerations in future research aiming to shed light on mechanisms of the GM-dyslipidemia axis.
Databáze:	MEDLINE
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