| Autor: |
Avilova IA; Federal Research Center for Problems of Chemical Physics and Medicinal Chemistry RAS, 142432 Chernogolovka, Russia., Chernyak AV; Federal Research Center for Problems of Chemical Physics and Medicinal Chemistry RAS, 142432 Chernogolovka, Russia.; Scientific Center in Chernogolovka RAS, 142432 Chernogolovka, Russia., Soldatova YV; Federal Research Center for Problems of Chemical Physics and Medicinal Chemistry RAS, 142432 Chernogolovka, Russia., Mumyatov AV; Federal Research Center for Problems of Chemical Physics and Medicinal Chemistry RAS, 142432 Chernogolovka, Russia., Kraevaya OA; Federal Research Center for Problems of Chemical Physics and Medicinal Chemistry RAS, 142432 Chernogolovka, Russia., Khakina EA; A.N. Nesmeyanov Institute of Organoelement Compounds RAS, 119334 Moscow, Russia., Troshin PA; Federal Research Center for Problems of Chemical Physics and Medicinal Chemistry RAS, 142432 Chernogolovka, Russia., Volkov VI; Federal Research Center for Problems of Chemical Physics and Medicinal Chemistry RAS, 142432 Chernogolovka, Russia.; Scientific Center in Chernogolovka RAS, 142432 Chernogolovka, Russia. |
| Abstrakt: |
Fullerene derivatives are of great interest in various fields of science and technology. Fullerene derivatives are known to have pronounced anticancer and antiviral activity. They have antibacterial properties. Their properties are largely determined by association processes. Understanding the nature and properties of associates in solvents of various types will make it possible to make significant progress in understanding the mechanisms of aggregation of molecules of fullerene derivatives in solutions. Thus, this work, aimed at studying the size and stability of associates, is relevant and promising for further research. The NMR method in a pulsed field gradient was used, which makes it possible to directly study the translational mobility of molecules. The sizes of individual molecules and associates were calculated based on the Stokes-Einstein model. The lifetime of associates was also estimated. The interaction of water-soluble C 60 fullerene derivatives with erythrocytes was also evaluated. The values of self-diffusion coefficients and the lifetime of molecules of their compounds in cell membranes are obtained. It is concluded that the molecules of fullerene derivatives are fixed on the cell surface, and their forward movement is controlled by lateral diffusion. |
