| Autor: |
Vrancianu CA; Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania.; Internal Medicine and Rheumatology Department, Cantacuzino Hospital, 020475 Bucharest, Romania., Gheorghiu AM; Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania.; Internal Medicine and Rheumatology Department, Cantacuzino Hospital, 020475 Bucharest, Romania., Popa DE; Cardiology Department, Theodor Burghele Hospital, 050653 Bucharest, Romania., Chan JSK; Epidemiology Research Unit, Cardiovascular Analytics Group, China-UK Collaboration, Hong Kong., Satti DI; Epidemiology Research Unit, Cardiovascular Analytics Group, China-UK Collaboration, Hong Kong., Lee YHA; Epidemiology Research Unit, Cardiovascular Analytics Group, China-UK Collaboration, Hong Kong., Hui JMH; Epidemiology Research Unit, Cardiovascular Analytics Group, China-UK Collaboration, Hong Kong., Tse G; Epidemiology Research Unit, Cardiovascular Analytics Group, China-UK Collaboration, Hong Kong.; Kent and Medway Medical School, Canterbury CT2 7FS, Kent, UK.; Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology, Second Hospital of Tianjin Medical University, Tianjin 300211, China., Ancuta I; Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania.; Internal Medicine and Rheumatology Department, Cantacuzino Hospital, 020475 Bucharest, Romania., Ciobanu A; Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania.; Cardiology Department, Theodor Burghele Hospital, 050653 Bucharest, Romania., Bojinca M; Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania.; Internal Medicine and Rheumatology Department, Cantacuzino Hospital, 020475 Bucharest, Romania. |
| Abstrakt: |
Systemic sclerosis (SSc) is an autoimmune disease characterized by skin and internal organ fibrosis and microvascular impairment, which can affect major organs, including the heart. Arrhythmias are responsible for approximately 6% of deaths in patients with SSc, and mainly occur due to myocardial fibrosis, which causes electrical inhomogeneity. The aim of this study was to determine the frequency of arrhythmias and conduction disturbances in SSc cohorts, and to identify the characteristics and risk factors associated with the occurrence of dysrhythmias in patients with SSc. A systematic literature review using PubMed, Embase, Web of Science and Scopus databases was performed. Full-text articles in English with arrhythmias as the main topic published until 21 April 2022 were included. Most prevalent arrhythmias were premature supraventricular and ventricular contractions, while the most frequent conduction disturbance was represented by right bundle branch block (RBBB). Elevated concentrations of N-terminal prohormones of brain natriuretic peptides (NT-pro BNP) were associated with numerous types of atrial and ventricular arrhythmias, and with the occurrence of RBBB. A lower value of the turbulence slope (TS) emerged as an independent predictor for ventricular arrhythmias. In conclusion, dysrhythmias are frequent in SSc cohorts. Paraclinical and laboratory parameters are useful instruments that could lead to early diagnosis in the course of the disease. |
