NAFLD in Polycystic Ovary Syndrome: Association with PNPLA3 and Metabolic Features.

Autor:	Recuero AM; Laboratório de Gastroenterologia Clínica e Experimental (LIM-07), Division of Clinical Gastroenterology and Hepatology, Department of Gastroenterology, Hospital das Clínicas, School of Medicine, University of Sao Paulo, Sao Paulo 048293, Brazil.; Division of Clinical Gastroenterology and Hepatology, Department of Gastroenterology, Hospital das Clínicas, School of Medicine, University of São Paulo, Sao Paulo 048293, Brazil., Gomes LG; Division of Endocrinology and Metabolism, School of Medicine, University of Sao Paulo, Sao Paulo 048293, Brazil., Maciel GAR; Division of Gynecological Clinic, School of Medicine, University of Sao Paulo, Sao Paulo 048293, Brazil., de Mello Malta F; Institute of Tropical Medicine, LIM 07, University of Sao Paulo, Sao Paulo 048293, Brazil., Salles APM; Institute of Tropical Medicine, LIM 07, University of Sao Paulo, Sao Paulo 048293, Brazil., Vezozzo DCP; Division of Clinical Gastroenterology and Hepatology, Department of Gastroenterology, Hospital das Clínicas, School of Medicine, University of São Paulo, Sao Paulo 048293, Brazil., Baracat EC; Division of Gynecological Clinic, School of Medicine, University of Sao Paulo, Sao Paulo 048293, Brazil., Pinho JRR; Institute of Tropical Medicine, LIM 07, University of Sao Paulo, Sao Paulo 048293, Brazil., Carrilho FJ; Laboratório de Gastroenterologia Clínica e Experimental (LIM-07), Division of Clinical Gastroenterology and Hepatology, Department of Gastroenterology, Hospital das Clínicas, School of Medicine, University of Sao Paulo, Sao Paulo 048293, Brazil.; Division of Clinical Gastroenterology and Hepatology, Department of Gastroenterology, Hospital das Clínicas, School of Medicine, University of São Paulo, Sao Paulo 048293, Brazil., Stefano JT; Laboratório de Gastroenterologia Clínica e Experimental (LIM-07), Division of Clinical Gastroenterology and Hepatology, Department of Gastroenterology, Hospital das Clínicas, School of Medicine, University of Sao Paulo, Sao Paulo 048293, Brazil., Oliveira CP; Laboratório de Gastroenterologia Clínica e Experimental (LIM-07), Division of Clinical Gastroenterology and Hepatology, Department of Gastroenterology, Hospital das Clínicas, School of Medicine, University of Sao Paulo, Sao Paulo 048293, Brazil.; Division of Clinical Gastroenterology and Hepatology, Department of Gastroenterology, Hospital das Clínicas, School of Medicine, University of São Paulo, Sao Paulo 048293, Brazil.
Jazyk:	angličtina
Zdroj:	Biomedicines [Biomedicines] 2022 Oct 27; Vol. 10 (11). Date of Electronic Publication: 2022 Oct 27.
DOI:	10.3390/biomedicines10112719
Abstrakt:	Background: The aim of this study was to determine the frequency of the rs738409 polymorphism in the patatin-like phospholipase domain containing 3 (PNPLA3) gene in patients with polycystic ovary syndrome (PCOS) and its impact on nonalcoholic fatty liver disease (NAFLD) risk and severity. We also evaluated other risk factors associated with NAFLD and advanced fibrosis. Methods: This was a cross-sectional study involving 163 patients with PCOS at a tertiary center. Genotyping for the PNPLA3 polymorphism was undertaken using a TaqMan assay. The degree of fibrosis was defined by transient elastography. Results: The prevalence of NAFLD was 72.4%, and the polymorphism was heterozygous in 41.7% and homozygous in 8% of patients. Homeostasis model assessment of insulin resistance ≥ 2.5 was the main factor associated with the risk of developing NAFLD (OR = 4.313, p = 0.022), and its effect was amplified by the polymorphism (OR = 12.198, p = 0.017). Age > 32 years also conferred a higher risk for NAFLD. HDL values ≥ 50 mg/dL conferred protection against the outcome. Metabolic syndrome (OR = 13.030, p = 0.020) and AST > 32 U/L (OR = 9.039, p = 0.009) were independent risk factors for advanced fibrosis. Conclusions: In women with PCOS, metabolic characteristics are more relevant than PNPLA3 polymorphism regarding the risk for NAFLD and its advanced forms, but these factors can act synergistically, increasing disease risk.
Databáze:	MEDLINE
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