Interplay between Immune Cell Infiltration and Tumor Histological Subtype: A Case of Adrenocortical Cancer.

Autor: Bogolyubova AV; National Research Center for Hematology, 125167 Moscow, Russia., Pachuashvili NV; Institute of Clinical Morphology and Digital Pathology, I.M. Sechenov First Moscow State Medical University, 119991 Moscow, Russia., Tkachuk AV; Endocrinology Research Centre, 117036 Moscow, Russia., Mokrysheva NG; Endocrinology Research Centre, 117036 Moscow, Russia., Urusova LS; Endocrinology Research Centre, 117036 Moscow, Russia.
Jazyk: angličtina
Zdroj: Cancers [Cancers (Basel)] 2022 Oct 28; Vol. 14 (21). Date of Electronic Publication: 2022 Oct 28.
DOI: 10.3390/cancers14215303
Abstrakt: The analysis of the tumor microenvironment, especially tumor-infiltrated immune cells, is essential for predicting tumor prognosis, clinical outcomes, and therapy strategies. Adrenocortical cancer is a rare nonimmunogenic malignancy in which the importance of the presence of immune cells is not well understood. In our study, we made the first attempt to understand the interplay between the histology of adrenocortical cancer and its immune landscape using cases from The Cancer Genome Atlas database and the Endocrinology Research Centre collection (Moscow, Russia). We showed that the oncocytic variant of adrenocortical cancer is characterized by intensive immune infiltration and better survival, and it is crucial to analyze the effect of immune infiltration independently for each histological variant.
Databáze: MEDLINE
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