Penile Squamous Cell Carcinomas in Sub-Saharan Africa and Europe: Differential Etiopathogenesis.

Autor: Manzotti C; Department of Pathology, Hospital Clínic of Barcelona, University of Barcelona, 08036 Barcelona, Spain.; Barcelona Institute of Global Health (ISGlobal), University of Barcelona, 08036 Barcelona, Spain., Chulo L; Department of Pathology, Maputo Central Hospital, Maputo 1106, Mozambique., López Del Campo R; Department of Pathology, Hospital Clínic of Barcelona, University of Barcelona, 08036 Barcelona, Spain., Trias I; Department of Pathology, Hospital Clínic of Barcelona, University of Barcelona, 08036 Barcelona, Spain., Del Pino M; Clinical Institute of Gynecology, Obstetrics, and Neonatology, Hospital Clínic of Barcelona, University of Barcelona, 08036 Barcelona, Spain., Saúde O; Department of Pathology, Maputo Central Hospital, Maputo 1106, Mozambique., Basílio I; Department of Pathology, Maputo Central Hospital, Maputo 1106, Mozambique., Tchamo N; Department of Urology, Maputo Central Hospital, Maputo 1106, Mozambique., Lovane L; Department of Pathology, Maputo Central Hospital, Maputo 1106, Mozambique., Lorenzoni C; Department of Pathology, Maputo Central Hospital, Maputo 1106, Mozambique.; Department of Pathology, Eduardo Mondlane University, Maputo 1106, Mozambique., Fernandes F; Department of Pathology, Maputo Central Hospital, Maputo 1106, Mozambique.; Department of Pathology, Eduardo Mondlane University, Maputo 1106, Mozambique., Saco A; Department of Pathology, Hospital Clínic of Barcelona, University of Barcelona, 08036 Barcelona, Spain., Rodrigo-Calvo MT; Department of Pathology, Hospital Clínic of Barcelona, University of Barcelona, 08036 Barcelona, Spain., Marimon L; Department of Pathology, Hospital Clínic of Barcelona, University of Barcelona, 08036 Barcelona, Spain.; Barcelona Institute of Global Health (ISGlobal), University of Barcelona, 08036 Barcelona, Spain., Ismail MR; Department of Pathology, Maputo Central Hospital, Maputo 1106, Mozambique.; Department of Pathology, Eduardo Mondlane University, Maputo 1106, Mozambique., Carrilho C; Department of Pathology, Maputo Central Hospital, Maputo 1106, Mozambique.; Department of Pathology, Eduardo Mondlane University, Maputo 1106, Mozambique., Ribera-Cortada I; Department of Pathology, Hospital Clínic of Barcelona, University of Barcelona, 08036 Barcelona, Spain., Ordi J; Department of Pathology, Hospital Clínic of Barcelona, University of Barcelona, 08036 Barcelona, Spain.; Barcelona Institute of Global Health (ISGlobal), University of Barcelona, 08036 Barcelona, Spain., Rakislova N; Department of Pathology, Hospital Clínic of Barcelona, University of Barcelona, 08036 Barcelona, Spain.; Barcelona Institute of Global Health (ISGlobal), University of Barcelona, 08036 Barcelona, Spain.
Jazyk: angličtina
Zdroj: Cancers [Cancers (Basel)] 2022 Oct 27; Vol. 14 (21). Date of Electronic Publication: 2022 Oct 27.
DOI: 10.3390/cancers14215284
Abstrakt: Penile squamous cell carcinomas (PSCC) are classified by the World Health Organization into two categories based on their relationship with the human papillomavirus (HPV): HPV-associated and HPV-independent. We compared a cohort of PSCC from Mozambique, a sub-Saharan country in southeast Africa with a high prevalence of HPV and HIV infection, and Spain, a country in southwestern Europe with a low prevalence of HPV and HIV, to study the distribution of the etiopathogenic categories of these tumors in both sites. A total of 79 PSCC were included in the study (28 from Mozambique and 51 from Spain). All cases underwent HPV-DNA polymerase chain reaction (PCR) testing, genotyping, and immunohistochemistry for p16 and p53. Any PSCC showing either p16 overexpression or HPV-DNA in PCR analysis was considered HPV-associated. Overall, 40/79 (50.6%) tumors were classified as HPV-associated and 39 (49.4%) as HPV-independent. The two sites showed marked differences: 25/28 (89.3%) tumors from Mozambique and only 15/51 (29.4%) from Spain were HPV-associated (p < 0.001). HPV16 was the most frequent HPV type identified in 64.0% (16/25) of the HPV-associated tumors from Mozambique, and 60.0% (9/15) from Spain (p = 0.8). On average, patients from Mozambique were almost two decades younger than those from Spain (mean age 50.9 ± 14.9 and 69.2 ± 13.3, respectively [p < 0.001]). In conclusion, significant etiopathogenic differences between PSCC in Mozambique and Spain were observed, with a remarkably high prevalence of HPV-associated tumors in Mozambique and a relatively low prevalence in Spain. These data may have important consequences for primary prevention of PSCC worldwide.
Databáze: MEDLINE
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