Divergent SARS-CoV-2 variant emerges in white-tailed deer with deer-to-human transmission.

Autor: Pickering B; National Centre for Foreign Animal Disease, Canadian Food Inspection Agency, Winnipeg, Manitoba, Canada. bradley.pickering@canada.ca.; Department of Veterinary Microbiology and Preventative Medicine, College of Veterinary Medicine, Iowa State University, Ames, IA, USA. bradley.pickering@canada.ca.; Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, Manitoba, Canada. bradley.pickering@canada.ca., Lung O; National Centre for Foreign Animal Disease, Canadian Food Inspection Agency, Winnipeg, Manitoba, Canada.; Department of Biological Sciences, University of Manitoba, Winnipeg, Manitoba, Canada., Maguire F; Faculty of Computer Science, Dalhousie University, Halifax, Nova Scotia, Canada.; Department of Community Health & Epidemiology, Dalhousie University, Halifax, Nova Scotia, Canada.; Shared Hospital Laboratory, Toronto, Ontario, Canada.; Sunnybrook Research Institute, Toronto, Ontario, Canada., Kruczkiewicz P; National Centre for Foreign Animal Disease, Canadian Food Inspection Agency, Winnipeg, Manitoba, Canada., Kotwa JD; Sunnybrook Research Institute, Toronto, Ontario, Canada., Buchanan T; Wildlife Research and Monitoring Section, Ontario Ministry of Natural Resources and Forestry, Peterborough, Ontario, Canada., Gagnier M; Ministère des Forêts, de la Faune et des Parcs, Quebec City, Quebec, Canada., Guthrie JL; Public Health Ontario, Toronto, Ontario, Canada.; Department of Microbiology & Immunology, Western University, London, Toronto, Ontario, Canada., Jardine CM; Canadian Wildlife Health Cooperative, Ontario-Nunavut, Department of Pathobiology, University of Guelph, Guelph, Ontario, Canada., Marchand-Austin A; Public Health Ontario, Toronto, Ontario, Canada., Massé A; Ministère des Forêts, de la Faune et des Parcs, Quebec City, Quebec, Canada., McClinchey H; Public Health, Health Protection and Surveillance Policy and Programs Branch, Ontario Ministry of Health, Toronto, Ontario, Canada., Nirmalarajah K; Sunnybrook Research Institute, Toronto, Ontario, Canada., Aftanas P; Shared Hospital Laboratory, Toronto, Ontario, Canada., Blais-Savoie J; Sunnybrook Research Institute, Toronto, Ontario, Canada., Chee HY; Sunnybrook Research Institute, Toronto, Ontario, Canada., Chien E; Sunnybrook Research Institute, Toronto, Ontario, Canada., Yim W; Sunnybrook Research Institute, Toronto, Ontario, Canada., Banete A; Sunnybrook Research Institute, Toronto, Ontario, Canada., Griffin BD; Sunnybrook Research Institute, Toronto, Ontario, Canada., Yip L; Sunnybrook Research Institute, Toronto, Ontario, Canada., Goolia M; National Centre for Foreign Animal Disease, Canadian Food Inspection Agency, Winnipeg, Manitoba, Canada., Suderman M; National Centre for Foreign Animal Disease, Canadian Food Inspection Agency, Winnipeg, Manitoba, Canada., Pinette M; National Centre for Foreign Animal Disease, Canadian Food Inspection Agency, Winnipeg, Manitoba, Canada., Smith G; National Centre for Foreign Animal Disease, Canadian Food Inspection Agency, Winnipeg, Manitoba, Canada., Sullivan D; National Centre for Foreign Animal Disease, Canadian Food Inspection Agency, Winnipeg, Manitoba, Canada.; Department of Biological Sciences, University of Manitoba, Winnipeg, Manitoba, Canada., Rudar J; National Centre for Foreign Animal Disease, Canadian Food Inspection Agency, Winnipeg, Manitoba, Canada., Vernygora O; National Centre for Foreign Animal Disease, Canadian Food Inspection Agency, Winnipeg, Manitoba, Canada., Adey E; Wildlife Research and Monitoring Section, Ontario Ministry of Natural Resources and Forestry, Peterborough, Ontario, Canada., Nebroski M; National Centre for Foreign Animal Disease, Canadian Food Inspection Agency, Winnipeg, Manitoba, Canada., Goyette G; Centre de Recherche du CHUM, Montréal, Quebec, Canada., Finzi A; Centre de Recherche du CHUM, Montréal, Quebec, Canada.; Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montréal, Quebec, Canada., Laroche G; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario, Canada.; Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, Ontario, Canada.; Centre for Infection, Immunity, and Inflammation, University of Ottawa, Ottawa, Ontario, Canada., Ariana A; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario, Canada.; Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, Ontario, Canada.; Centre for Infection, Immunity, and Inflammation, University of Ottawa, Ottawa, Ontario, Canada., Vahkal B; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario, Canada.; Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, Ontario, Canada.; Centre for Infection, Immunity, and Inflammation, University of Ottawa, Ottawa, Ontario, Canada., Côté M; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario, Canada.; Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, Ontario, Canada.; Centre for Infection, Immunity, and Inflammation, University of Ottawa, Ottawa, Ontario, Canada., McGeer AJ; Sinai Health System, Toronto, Ontario, Canada.; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada., Nituch L; Wildlife Research and Monitoring Section, Ontario Ministry of Natural Resources and Forestry, Peterborough, Ontario, Canada., Mubareka S; Sunnybrook Research Institute, Toronto, Ontario, Canada. samira.mubareka@sunnybrook.ca.; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada. samira.mubareka@sunnybrook.ca., Bowman J; Wildlife Research and Monitoring Section, Ontario Ministry of Natural Resources and Forestry, Peterborough, Ontario, Canada. jeff.bowman@ontario.ca.; Environmental and Life Sciences Graduate Program, Trent University, Peterborough, Ontario, Canada. jeff.bowman@ontario.ca.
Jazyk: angličtina
Zdroj: Nature microbiology [Nat Microbiol] 2022 Dec; Vol. 7 (12), pp. 2011-2024. Date of Electronic Publication: 2022 Nov 10.
DOI: 10.1038/s41564-022-01268-9
Abstrakt: Wildlife reservoirs of broad-host-range viruses have the potential to enable evolution of viral variants that can emerge to infect humans. In North America, there is phylogenomic evidence of continual transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) from humans to white-tailed deer (Odocoileus virginianus) through unknown means, but no evidence of transmission from deer to humans. We carried out an observational surveillance study in Ontario, Canada during November and December 2021 (n = 300 deer) and identified a highly divergent lineage of SARS-CoV-2 in white-tailed deer (B.1.641). This lineage is one of the most divergent SARS-CoV-2 lineages identified so far, with 76 mutations (including 37 previously associated with non-human mammalian hosts). From a set of five complete and two partial deer-derived viral genomes we applied phylogenomic, recombination, selection and mutation spectrum analyses, which provided evidence for evolution and transmission in deer and a shared ancestry with mink-derived virus. Our analysis also revealed an epidemiologically linked human infection. Taken together, our findings provide evidence for sustained evolution of SARS-CoV-2 in white-tailed deer and of deer-to-human transmission.
(© 2022. The Author(s).)
Databáze: MEDLINE
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