Exploitation of cantaloupe peels for bacterial cellulose production and functionalization with green synthesized Copper oxide nanoparticles for diverse biological applications.
Autor: | Saleh AK; Cellulose and Paper Department, National Research Centre, El-Tahrir St., Post 12622, Dokki, Giza, Egypt. asrk_saleh@yahoo.com., El-Gendi H; Bioprocess Development Department, Genetic Engineering and Biotechnology Research Institute, City of Scientific Research and Technological Applications (SRTA-City), New Borg El-Arab City, 21934, Alexandria, Egypt. elgendi1981@yahoo.com., El-Fakharany EM; Protein Research Department, Genetic Engineering and Biotechnology Research Institute, City of Scientific Research and Technological Applications (SRTA-City), New Borg El-Arab City, 21934, Alexandria, Egypt., Owda ME; Chemistry Department, Faculty of Science, Al-Azhar University, Nasr City, 11884, Cairo, Egypt., Awad MA; Zoology and Entomology Department, Faculty of Science, Al-Azhar University, Nasr City, Cairo, Egypt., Kamoun EA; Nanotechnology Research Center (NTRC), The British University in Egypt (BUE), El-Sherouk City, 11837, Cairo, Egypt.; Polymeric Materials Research Department, Advanced Technology and New Materials Research Institute (ATNMRI), City of Scientific Research and Technological Applications (SRTA-City), New Borg El-Arab City, 21934, Alexandria, Egypt. |
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Jazyk: | angličtina |
Zdroj: | Scientific reports [Sci Rep] 2022 Nov 10; Vol. 12 (1), pp. 19241. Date of Electronic Publication: 2022 Nov 10. |
DOI: | 10.1038/s41598-022-23952-w |
Abstrakt: | The promising features of most bacterial celluloses (BC) promote the continuous mining for a cost-effective production approach toward wide and sustainable applications. Herein, cantaloupe peels (CP) were successfully implemented for sustainable BC production. Results indicated that the enzymatically hydrolyzed CP supported the maximum BC production of approximately 3.49 g/L when used as a sole fermentation media. The produced BC was fabricated with polyvinyl alcohol (PVA) and chitosan (Ch), and loaded with green synthesized copper oxide nanoparticles (CuO-NPs) to improve its biological activity. The novel composite showed an antimicrobial activity against several human pathogens such as Staphylococcus aureus, Streptococcus mutans, Salmonella typhimurium, Escherichia coli, and Pseudomonas fluorescens. Furthermore, the new composite revealed a significant in vitro anticancer activity against colon (Caco-2), hepatocellular (HepG-2), and breast (MDA) cancer cells, with low IC (© 2022. The Author(s).) |
Databáze: | MEDLINE |
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