B cell responses to the gut microbiota.
| Autor: | Ng KW; Laboratory of Lymphocyte Dynamics, The Rockefeller University, New York, NY, United States., Hobbs A; Laboratory of Lymphocyte Dynamics, The Rockefeller University, New York, NY, United States., Wichmann C; Laboratory of Lymphocyte Dynamics, The Rockefeller University, New York, NY, United States; Laboratory of Mucosal Immunology, The Rockefeller University, New York, NY, United States; Immune Regulation Group, Department of Pediatrics, University Medical Center Rostock, Rostock, Germany., Victora GD; Laboratory of Lymphocyte Dynamics, The Rockefeller University, New York, NY, United States. Electronic address: victora@rockefeller.edu., Donaldson GP; Laboratory of Mucosal Immunology, The Rockefeller University, New York, NY, United States. Electronic address: gdonaldson@rockefeller.edu. |
|---|---|
| Jazyk: | angličtina |
| Zdroj: | Advances in immunology [Adv Immunol] 2022; Vol. 155, pp. 95-131. Date of Electronic Publication: 2022 Oct 14. |
| DOI: | 10.1016/bs.ai.2022.08.003 |
| Abstrakt: | Most antibody produced by humans originates from mucosal B cell responses. The rules, mechanisms, and outcomes of this process are distinct from B cell responses to infection. Within the context of the intestine, we discuss the induction of follicular B cell responses by microbiota, the development and maintenance of mucosal antibody-secreting cells, and the unusual impacts of mucosal antibody on commensal bacteria. Much remains to be learned about the interplay between B cells and the microbiota, but past and present work hints at a complex, nuanced relationship that may be critical to the way the mammalian gut fosters a beneficial microbial ecosystem. (Copyright © 2022 Elsevier Inc. All rights reserved.) |
| Databáze: | MEDLINE |
| Externí odkaz: |
|