Continuous Rather Than Solely Early Farm Exposure Protects From Hay Fever Development.

Autor:	Pechlivanis S; Institute of Asthma and Allergy Prevention, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany. Electronic address: sonali.pechlivanis@helmholtz-muenchen.de., Depner M; Institute of Asthma and Allergy Prevention, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Kirjavainen PV; Department of Health Security, Finnish Institute for Health and Welfare, Kuopio, Finland; Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland., Roduit C; Christine Kühne Center for Allergy Research and Education (CK-CARE), Davos, Switzerland; Children's Hospital, University of Zurich, Zurich, Switzerland; Children's Hospital of Eastern Switzerland, St. Gallen, Switzerland., Täubel M; Department of Health Security, Finnish Institute for Health and Welfare, Kuopio, Finland., Frei R; Christine Kühne Center for Allergy Research and Education (CK-CARE), Davos, Switzerland; Division of Respiratory Medicine, Department of Paediatrics, Inselspital, University of Bern, Bern, Switzerland., Skevaki C; Institute of Laboratory Medicine, Universities of Giessen and Marburg Lung Center (UGMLC), Philipps University Marburg, Marburg, Germany; Member of the German Center for Lung Research, Gießen, Germany., Hose A; Dr. von Hauner Children's Hospital, Ludwig Maximilians University Munich, Munich, Germany., Barnig C; Institut national de la santé et de la recherche médicale, Établissement français du sang Bourgogne-Franche-Comté, LabEx LipSTIC, Unité Mixte de recherche 1098, Interactions Hôte-Greffon-Tumeur/Ingénierie Cellulaire et Génique, Univ. Bourgogne Franche-Comté, Besançon, France; Department of Chest Disease, University Hospital of Besançon, Besançon, France., Schmausser-Hechfellner E; Institute of Asthma and Allergy Prevention, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Ege MJ; Institute of Asthma and Allergy Prevention, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany; Member of the German Center for Lung Research, Gießen, Germany; Dr. von Hauner Children's Hospital, Ludwig Maximilians University Munich, Munich, Germany., Schaub B; Member of the German Center for Lung Research, Gießen, Germany; Dr. von Hauner Children's Hospital, Ludwig Maximilians University Munich, Munich, Germany., Divaret-Chauveau A; Pediatric Allergy Department, Children's Hospital, University Hospital of Nancy, Vandoeuvre les Nancy, Nancy, France; UMR 6249 Chrono-environment, Centre National de la Recherche Scientifique and University of Franche-Comté, Besançon, France; EA3450 Development, Adaptation and Handicap, University of Lorraine, Nancy, France., Lauener R; Christine Kühne Center for Allergy Research and Education (CK-CARE), Davos, Switzerland; Children's Hospital of Eastern Switzerland, St. Gallen, Switzerland., Karvonen AM; Department of Health Security, Finnish Institute for Health and Welfare, Kuopio, Finland., Pekkanen J; Department of Health Security, Finnish Institute for Health and Welfare, Kuopio, Finland; Department of Public Health, University of Helsinki, Helsinki, Finland., Riedler J; Children's Hospital Schwarzach, Schwarzach, Austria., Illi S; Institute of Asthma and Allergy Prevention, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., von Mutius E; Institute of Asthma and Allergy Prevention, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany; Member of the German Center for Lung Research, Gießen, Germany; Dr. von Hauner Children's Hospital, Ludwig Maximilians University Munich, Munich, Germany.
Jazyk:	angličtina
Zdroj:	The journal of allergy and clinical immunology. In practice [J Allergy Clin Immunol Pract] 2023 Feb; Vol. 11 (2), pp. 591-601. Date of Electronic Publication: 2022 Nov 07.
DOI:	10.1016/j.jaip.2022.10.035
Abstrakt:	Background: An important window of opportunity for early-life exposures has been proposed for the development of atopic eczema and asthma. Objective: However, it is unknown whether hay fever with a peak incidence around late school age to adolescence is similarly determined very early in life. Methods: In the Protection against Allergy-Study in Rural Environments (PASTURE) birth cohort potentially relevant exposures such as farm milk consumption and exposure to animal sheds were assessed at multiple time points from infancy to age 10.5 years and classified by repeated measure latent class analyses (n = 769). Fecal samples at ages 2 and 12 months were sequenced by 16S rRNA. Hay fever was defined by parent-reported symptoms and/or physician's diagnosis of hay fever in the last 12 months using questionnaires at 10.5 years. Results: Farm children had half the risk of hay fever at 10.5 years (adjusted odds ratio [aOR] 0.50; 95% CI 0.31-0.79) than that of nonfarm children. Whereas early life events such as gut microbiome richness at 12 months (aOR 0.66; 95% CI 0.46-0.96) and exposure to animal sheds in the first 3 years of life (aOR 0.26; 95% CI 0.06-1.15) were determinants of hay fever, the continuous consumption of farm milk from infancy up to school age was necessary to exert the protective effect (aOR 0.35; 95% CI 0.17-0.72). Conclusions: While early life events determine the risk of subsequent hay fever, continuous exposure is necessary to achieve protection. These findings argue against the notion that only early life exposures set long-lasting trajectories. (Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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