Dietary patterns and urinary phthalate exposure among postmenopausal women of the Women's Health Initiative.

Autor: Vieyra G; Department of Biostatistics and Epidemiology, University of Massachusetts Amherst, Amherst, MA, 01003, USA. Electronic address: gvieyra@umass.edu., Hankinson SE; Department of Biostatistics and Epidemiology, University of Massachusetts Amherst, Amherst, MA, 01003, USA., Oulhote Y; Department of Biostatistics and Epidemiology, University of Massachusetts Amherst, Amherst, MA, 01003, USA., Vandenberg L; Department of Environmental Health Sciences, University of Massachusetts Amherst, Amherst, Ma, 01003, USA., Tinker L; Department of Cancer Prevention, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109, USA., Mason J; Department of Medicine, Brigham and Women's Hospital, and Epidemiology, Harvard T.H. Chan School, Boston, MA, 02115, USA., Shadyab AH; Herbert Wertheim School of Public Health and Human Longevity Science, University of California, San Diego, La Jolla, CA, USA., Wallace R; Department of Epidemiology and Internal Medicine, University of Iowa, USA., Arcan C; Department of Family Medicine and Population Health, Virginia Commonwealth University, Richmond, VA, USA., Chen JC; Department of Population & Public Health Sciences and Department of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Reeves KW; Department of Biostatistics and Epidemiology, University of Massachusetts Amherst, Amherst, MA, 01003, USA. Electronic address: kwreeves@umass.edu.
Jazyk: angličtina
Zdroj: Environmental research [Environ Res] 2023 Jan 01; Vol. 216 (Pt 3), pp. 114727. Date of Electronic Publication: 2022 Nov 07.
DOI: 10.1016/j.envres.2022.114727
Abstrakt: Background: Phthalates are endocrine-disrupting chemicals linked to a higher risk of numerous chronic health outcomes. Diet is a primary source of exposure, but prior studies exploring associations between dietary patterns and phthalate exposure are limited.
Objectives: We evaluated the associations between dietary patterns and urinary phthalate biomarkers among a subset of postmenopausal women participating in the Women's Health Initiative (WHI).
Methods: We included WHI participants selected for a nested case-control study of phthalates and breast cancer (N = 1240). Dietary intake was measured via self-administered food frequency questionnaires at baseline and year-3. We used these data to calculate scores for alignment with the Dietary Approach to Stop Hypertension (DASH), alternative Mediterranean (aMed), and Dietary Inflammatory Index (DII) diets. We measured 13 phthalate metabolites and creatinine in 2-3 urine samples per participant collected over 3-years when all participants were cancer-free. We fit multivariable generalized estimating equation models to estimate the cross-sectional associations.
Results: DASH and aMed dietary scores were inversely associated with the sum of di(2-Ethylhexyl) phthalate (-6.48%, 95% CI -9.84, -3.00; -5.23%, 95% CI -8.73, -1.60) and DII score was positively associated (9.00%, 95% CI 5.04, 13.11). DASH and aMed scores were also inversely associated with mono benzyl phthalate and mono-3-carboxypropyl phthalate. DII scores were positively associated with mono benzyl phthalate and the sum of di-n-butyl phthalate.
Discussion: Higher dietary alignment with DASH and aMed dietary patterns were significantly associated with lower concentrations of certain phthalate biomarkers, while an inflammatory diet pattern was associated with higher phthalate biomarker concentrations. These findings suggest that dietary patterns high in fruits, vegetables, and low-fat foods and low in processed foods may be useful in avoiding exposure to phthalates.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2022 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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