Porcine spinal cord injury model for translational research across multiple functional systems.

Autor: Ahmed RU; Department of Neurological Surgery and Kentucky Spinal Cord Injury Research Center, University of Louisville, Louisville, KY, USA. Electronic address: rakibuddin.ahmed@louisville.edu., Knibbe CA; Department of Neurological Surgery and Kentucky Spinal Cord Injury Research Center, University of Louisville, Louisville, KY, USA., Wilkins F; Department of Neurological Surgery and Kentucky Spinal Cord Injury Research Center, University of Louisville, Louisville, KY, USA., Sherwood LC; Comparative Medicine Research Unit, University of Louisville, Louisville, KY, USA., Howland DR; Department of Neurological Surgery and Kentucky Spinal Cord Injury Research Center, University of Louisville, Louisville, KY, USA; Robley Rex VA Medical Center, Louisville, KY 40202, USA., Boakye M; Department of Neurological Surgery and Kentucky Spinal Cord Injury Research Center, University of Louisville, Louisville, KY, USA.
Jazyk: angličtina
Zdroj: Experimental neurology [Exp Neurol] 2023 Jan; Vol. 359, pp. 114267. Date of Electronic Publication: 2022 Nov 07.
DOI: 10.1016/j.expneurol.2022.114267
Abstrakt: Animal models are necessary to identify pathological changes and help assess therapeutic outcomes following spinal cord injury (SCI). Small animal models offer value in research in terms of their easily managed size, minimal maintenance requirements, lower cost, well-characterized genomes, and ability to power research studies. However, despite these benefits, small animal models have neurologic and anatomical differences that may influence translation of results to humans and thus limiting the success of their use in preclinical studies as a direct pipeline to clinical studies. Large animal models, offer an attractive intermediary translation model that may be more successful in translating to the clinic for SCI research. This is largely due to their greater neurologic and anatomical similarities to humans. The physical characteristics of pig spinal cord, gut microbiome, metabolism, proportions of white to grey matter, bowel anatomy and function, and urinary system are strikingly similar and provide great insight into human SCI conditions. In this review, we address the variety of existing porcine injury models and their translational relevance, benefits, and drawbacks in modeling human systems and functions for neurophysiology, cardiovascular, gastrointestinal and urodynamic functions.
(Copyright © 2022 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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