| Autor: |
Alcala CS; Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Lichtveld MY; Environmental and Occupational Health, University of Pittsburgh School of Public Health, Pittsburgh, PA 15261, USA., Wickliffe JK; Environmental Health Sciences, University of Alabama at Birmingham, Birmingham, AL 35233, USA., Zijlmans W; Faculty of Medical Sciences, Anton de Kom University of Suriname, Paramaribo, Suriname., Shankar A; Department of Biostatistics and Data Science, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA 70112, USA., Rokicki E; Department of Environmental Health Sciences, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA 70112, USA., Covert H; Environmental and Occupational Health, University of Pittsburgh School of Public Health, Pittsburgh, PA 15261, USA., Abdoel Wahid FZ; Faculty of Medical Sciences, Anton de Kom University of Suriname, Paramaribo, Suriname.; Scientific Research Center Suriname, Academic Hospital Paramaribo, Paramaribo, Suriname., Hindori-Mohangoo AD; Department of Environmental Health Sciences, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA 70112, USA.; Foundation for Perinatal Interventions and Research in Suriname (Perisur), Paramaribo, Suriname., van Sauers-Muller A; Pesticide Division, Ministry of Agriculture, Animal Husbandry, and Fisheries of Suriname, Paramaribo, Suriname., van Dijk C; Pesticide Division, Ministry of Agriculture, Animal Husbandry, and Fisheries of Suriname, Paramaribo, Suriname., Roosblad J; Clinical Chemical Laboratory, Academic Hospital Paramaribo, Paramaribo, Suriname., Codrington J; Clinical Chemical Laboratory, Academic Hospital Paramaribo, Paramaribo, Suriname., Wilson MJ; Department of Environmental Health Sciences, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA 70112, USA. |
| Abstrakt: |
Prenatal exposure to pesticides and the association with adverse health outcomes have been examined in several studies. However, the characterization of pesticide exposure among Surinamese women during pregnancy has not been assessed. As part of the Caribbean Consortium of Research in Environmental and Occupational Health research program, 214 urine samples were collected from pregnant women living in three regions in Suriname with different agricultural practices: capital Paramaribo, the rice producing district Nickerie, and the tropical rainforest, the Interior. We used isotope dilution tandem mass spectrometry to quantify urinary concentrations of biomarkers of three pesticide classes, including phenoxy acid herbicides and organophosphate and pyrethroid insecticides, all of which are commonly used in agricultural and residential settings in Suriname. We observed that participants residing in Nickerie had the highest urinary metabolite concentrations of 2,4-dichlorophenoxyacetic acid and pyrethroids compared to those from Paramaribo or the Interior. Paramaribo had the highest concentrations of organophosphate metabolites, specifically dialkyl phosphate metabolites. Para-nitrophenol was detected in samples from Paramaribo and the Interior. Samples from Nickerie had higher median urinary pesticide concentrations of 2,4-dichlorophenoxyacetic acid (1.06 μg/L), and the following metabolites, 3,5,6-trichloro-2-pyridinol (1.26 μg/L), 2-isopropyl-4-methyl-6-hydroxypyrimidine (0.60 μg/L), and 3-phenoxybenzoic acid (1.34 μg/L), possibly due to residential use and heavy rice production. |
