Robotic multi-probe single-actuator inchworm neural microdrive.
| Autor: | Smith RD; Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States., Kolb I; Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States., Tanaka S; Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States., Lee AK; Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States., Harris TD; Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States., Barbic M; Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States. |
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| Jazyk: | angličtina |
| Zdroj: | ELife [Elife] 2022 Nov 10; Vol. 11. Date of Electronic Publication: 2022 Nov 10. |
| DOI: | 10.7554/eLife.71876 |
| Abstrakt: | A wide range of techniques in neuroscience involve placing individual probes at precise locations in the brain. However, large-scale measurement and manipulation of the brain using such methods have been severely limited by the inability to miniaturize systems for probe positioning. Here, we present a fundamentally new, remote-controlled micropositioning approach composed of novel phase-change material-filled resistive heater micro-grippers arranged in an inchworm motor configuration. The microscopic dimensions, stability, gentle gripping action, individual electronic control, and high packing density of the grippers allow micrometer-precision independent positioning of many arbitrarily shaped probes using a single piezo actuator. This multi-probe single-actuator design significantly reduces the size and weight and allows for potential automation of microdrives. We demonstrate accurate placement of multiple electrodes into the rat hippocampus in vivo in acute and chronic preparations. Our robotic microdrive technology should therefore enable the scaling up of many types of multi-probe applications in neuroscience and other fields. Competing Interests: RS, MB M.B. and R.D.S. have applied for intellectual property patent protection on the devices and principles described in this work ("Positioning apparatus and gripping apparatus", US20200046317A1), IK, ST, AL, TH No competing interests declared (© 2022, Smith et al.) |
| Databáze: | MEDLINE |
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